UniProt Accession

 NKX21_RAT; P23441; O08630; O70121 

Genbank Protein ID

 X53858; D38035 

Genbank Nucleotide ID

 CAA37851.1; BAA07231.1 

Protein Name

 Homeobox protein Nkx-2.1 

Protein Synonyms/Alias

 Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1 

Gene Name

 Nkx2-1 

Gene Synonyms/Alias

 Nkx-2.1; Titf1; Ttf-1; Ttf1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
163	LPSAPRRKRRVLFSQ	acetylation	[1]
181	YELERRFKQQKYLSA	acetylation	[1]
184	ERRFKQQKYLSAPER	acetylation	[1]
206	HLTPTQVKIWFQNHR	acetylation	[1]
215	WFQNHRYKMKRQAKD	acetylation	[1]
223	MKRQAKDKAAQQQLQ	acetylation	[1]

Reference

 [1] Topology of the thyroid transcription factor 1 homeodomain-DNA complex.
 Scaloni A, Monti M, Acquaviva R, Tell G, Damante G, Formisano S, Pucci P.
 Biochemistry. 1999 Jan 5;38(1):64-72. [PMID: 9890883] 

Functional Description

 Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. 

Sequence Annotation

 DNA_BIND 161 220 Homeobox.  

Keyword

 3D-structure; Activator; Complete proteome; DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0046545; P:development of primary female sexual characteristics; IEP:RGD.
 GO:0007631; P:feeding behavior; IMP:RGD.
 GO:0042538; P:hyperosmotic salinity response; IDA:RGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0002016; P:regulation of blood volume by renin-angiotensin; IDA:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0032496; P:response to lipopolysaccharide; IDA:RGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS

 PR00024; HOMEOBOX.