UniProt Accession

 DHSB_RAT; P21913; B0BMZ2; Q0QEZ3 

Genbank Protein ID

 CH473968; BC158620; DQ403001 

Genbank Nucleotide ID

 EDL80954.1; AAI58621.1; ABD77134.1 

Protein Name

 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 

Protein Synonyms/Alias

 Iron-sulfur subunit of complex II; Ip 

Gene Name

 Sdhb 

Gene Synonyms/Alias

 Sdh1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
42	AAAAPRIKTFAIYRW	acetylation	[1]
53	IYRWDPDKAGDKPRM	acetylation	[1]
57	DPDKAGDKPRMQTYK	acetylation	[1]
64	KPRMQTYKVDLNKCG	acetylation	[1]
69	TYKVDLNKCGPMVLD	acetylation	[1]
82	LDALIKIKNEIDSTL	acetylation	[1]
125	RIDTDLGKVSKIYPL	acetylation	[1]
128	TDLGKVSKIYPLPHM	acetylation	[1]
153	SNFYAQYKSIEPYLK	acetylation	[1]
160	KSIEPYLKKKDESQE	acetylation	[1]
235	FTEERLAKLQDPFSL	acetylation	[1]
269	GKAIAEIKKMMATYK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). 

Sequence Annotation

 DOMAIN 56 135 2Fe-2S ferredoxin-type.
 DOMAIN 178 208 4Fe-4S ferredoxin-type.
 METAL 95 95 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 100 100 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 103 103 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 115 115 Iron-sulfur 1 (2Fe-2S) (By similarity).
 METAL 188 188 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 191 191 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 194 194 Iron-sulfur 2 (4Fe-4S) (By similarity).
 METAL 198 198 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 245 245 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 251 251 Iron-sulfur 3 (3Fe-4S) (By similarity).
 METAL 255 255 Iron-sulfur 2 (4Fe-4S) (By similarity).
 BINDING 203 203 Ubiquinone; shared with DHSD (By  

Keyword

 2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Reference proteome; Transit peptide; Transport; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 282 AA 

Protein Sequence

Gene Ontology

 GO:0005749; C:mitochondrial respiratory chain complex II; ISS:UniProtKB.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; ISS:UniProtKB.
 GO:0051538; F:3 iron, 4 sulfur cluster binding; ISS:UniProtKB.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; ISS:UniProtKB.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IMP:RGD.
 GO:0048039; F:ubiquinone binding; ISS:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; IMP:RGD.
 GO:0006105; P:succinate metabolic process; IMP:RGD.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001041; 2Fe-2S_ferredoxin-type.
 IPR006058; 2Fe2S_fd_BS.
 IPR017896; 4Fe4S_Fe-S-bd.
 IPR017900; 4Fe4S_Fe_S_CS.
 IPR012675; Beta-grasp_dom.
 IPR012285; Fum_reductase_C.
 IPR009051; Helical_ferredxn.
 IPR004489; Succ_DH/fum_Rdtase_Fe-S.
 IPR025192; Succ_DH/fum_Rdtase_N. 

Pfam

 PF13085; Fer2_3 

SMART

  

PROSITE

 PS00197; 2FE2S_FER_1
 PS51085; 2FE2S_FER_2
 PS00198; 4FE4S_FER_1
 PS51379; 4FE4S_FER_2 

PRINTS