CPLM-010753

Genbank Nucleotide ID

Phosphate carrier protein, mitochondrial

Protein Synonyms/Alias

Phosphate transport protein; PTP; Solute carrier family 25 member 3

Homo sapiens (Human)

Position	Peptide	Type	References
99	RMQVDPQKYKGIFNG	acetylation	[1, 2]
99	RMQVDPQKYKGIFNG	ubiquitination	[3, 4, 5]
101	QVDPQKYKGIFNGFS	ubiquitination	[3, 5]
112	NGFSVTLKEDGVRGL	ubiquitination	[3, 5]
121	DGVRGLAKGWAPTFL	ubiquitination	[3, 5]
206	TLRDAAPKMYKEEGL	ubiquitination	[3, 4, 5]
209	DAAPKMYKEEGLKAF	acetylation	[1, 2]
209	DAAPKMYKEEGLKAF	ubiquitination	[3, 4, 5]
214	MYKEEGLKAFYKGVA	acetylation	[1]
214	MYKEEGLKAFYKGVA	ubiquitination	[3, 4, 5]
218	EGLKAFYKGVAPLWM	ubiquitination	[3, 5, 6]
234	QIPYTMMKFACFERT	ubiquitination	[3, 5]
247	RTVEALYKFVVPKPR	ubiquitination	[3, 5]
252	LYKFVVPKPRSECSK	ubiquitination	[3, 5]
295	VSVLNKEKGSSASLV	ubiquitination	[4]
304	SSASLVLKRLGFKGV	ubiquitination	[3, 4, 5]
309	VLKRLGFKGVWKGLF	ubiquitination	[3, 5]
355	PEMPESLKKKLGLTQ	ubiquitination	[4]
357	MPESLKKKLGLTQ**	ubiquitination	[4]

[1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
[3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]

Functional Description

Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).

REPEAT 63 147 Solcar 1.
REPEAT 160 244 Solcar 2.
REPEAT 261 339 Solcar 3.
MOD_RES 99 99 N6-acetyllysine.
MOD_RES 196 196 Phosphotyrosine.
MOD_RES 209 209 N6-acetyllysine (By similarity).

Acetylation; Alternative splicing; Complete proteome; Disease mutation; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Repeat; Symport; Transit peptide; Transmembrane; Transmembrane helix; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0005743; C:mitochondrial inner membrane; TAS:ProtInc.
GO:0015320; F:phosphate ion carrier activity; TAS:ProtInc.
GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.

IPR018108; Mitochondrial_sb/sol_carrier.
IPR023395; Mt_carrier_dom.