CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tether containing UBX domain for GLUT4 
Protein Synonyms/Alias
 Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9 
Gene Name
 ASPSCR1 
Gene Synonyms/Alias
 ASPL; RCC17; TUG; UBXD9; UBXN9 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
75ANLPNNAKLEMVPASubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by METTL21D. 
Sequence Annotation
 DOMAIN 386 462 UBX.
 REGION 317 380 Interaction with GLUT4 (By similarity).
 MOD_RES 500 500 Phosphoserine.  
Keyword
 Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 553 AA 
Protein Sequence
MAAPAGGGGS AVSVLAPNGR RHTVKVTPST VLLQVLEDTC RRQDFNPCEY DLKFQRSVLD 60
LSLQWRFANL PNNAKLEMVP ASRSREGPEN MVRIALQLDD GSRLQDSFCS GQTLWELLSH 120
FPQIRECLQH PGGATPVCVY TRDEVTGEAA LRGTTLQSLG LTGGSATIRF VMKCYDPVGK 180
TPGSLGSSAS AGQAAASAPL PLESGELSRG DLSRPEDADT SGPCCEHTQE KQSTRAPAAA 240
PFVPFSGGGQ RLGGPPGPTR PLTSSSAKLP KSLSSPGGPS KPKKSKSGQD PQQEQEQERE 300
RDPQQEQERE RPVDREPVDR EPVVCHPDLE ERLQAWPAEL PDEFFELTVD DVRRRLAQLK 360
SERKRLEEAP LVTKAFREAQ IKEKLERYPK VALRVLFPDR YVLQGFFRPS ETVGDLRDFV 420
RSHLGNPELS FYLFITPPKT VLDDHTQTLF QPQLGDRVAP FTLGPSLKRC LGPEQRTRLP 480
VVGDGGDVDS GRLLFWGPSR GRASPSTGQP PCHPVCRPSS PPSPRPSSGD PSRVKAGHKH 540
VGTGRANLFP AALVHLGAEE PAGVYLEPGL LEHAISPSAA DVLVARYMSR AAGSPSPLPA 600
PDPAPKSEPA AEEGALVPPE PIPGTAQPVK RSLGKVPKWL KLPASKR 647 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0019898; C:extrinsic to membrane; IEA:Compara.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0012506; C:vesicle membrane; IEA:Compara.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0046324; P:regulation of glucose import; IEA:Compara. 
Interpro
 IPR021569; TUG.
 IPR001012; UBX. 
Pfam
 PF11470; TUG
 PF00789; UBX 
SMART
 SM00166; UBX 
PROSITE
 PS50033; UBX 
PRINTS