| Tag | Content |
|---|
| CPLM ID | CPLM-016762 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Death-inducer obliterator 1 |
Protein Synonyms/Alias | DIO-1; Death-associated transcription factor 1; DATF-1 |
Gene Name | Dido1 |
Gene Synonyms/Alias | Datf1; Dio1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1523 | PPKSSLGKTELFSQE | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Putative transcription factor, weakly pro-apoptotic when overexpressed. |
Sequence Annotation | DOMAIN 667 787 TFIIS central.
ZN_FING 265 319 PHD-type.
MOTIF 162 170 Nuclear localization signal (Potential).
MOTIF 182 190 Nuclear localization signal (Potential).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 8 8 Phosphoserine.
MOD_RES 148 148 Phosphothreonine.
MOD_RES 149 149 Phosphoserine (By similarity).
MOD_RES 151 151 Phosphoserine (By similarity).
MOD_RES 802 802 Phosphoserine.
MOD_RES 806 806 Phosphoserine (By similarity).
MOD_RES 1016 1016 Phosphoserine (By similarity).
MOD_RES 1027 1027 Phosphoserine (By similarity).
MOD_RES 1035 1035 Phosphoserine (By similarity).
MOD_RES 1256 1256 Phosphoserine.
MOD_RES 1307 1307 Phosphoserine (By similarity).
MOD_RES 1514 1514 Phosphoserine (By similarity).
MOD_RES 1726 1726 Phosphoserine (By similarity). |
Keyword | 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2256 AA |
Protein Sequence | MDDKGHLSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDTEVDPSEQ QPQQHNLSLR 60
RSGRQPKRTE RVEEFLTTVR RRGKKNVPVS LEDSSEPTSS TVTDVETASE GSVESSSEIR 120
SGPVSDSLGK EHPASSEKAK GGEEEEDTSD SDSDGLTLKE LQNRLRRKRE QEPVERSLRG 180
SQNRLRKKRR EEDSAETGSV QIGSAEQDRP LCKQEPEASQ GPVSQSETDD IENQLEGKAT 240
QGNTEENPRE AGKPKPECEV YDPNALYCIC RQPHNNRFMI CCDRCEEWFH GDCVGISEAR 300
GRLLERNGED YICPNCTILQ VQDETNGSAT DEQDSGCRSV GADGTDCTSI GTVEQKSGED 360
QGIKGRIEKA ANPSGKKKLK IFQPVVEAPG APKCIGPGCS SVAQPDSVYC SNDCILKHAA 420
ATMRFLSSGK EQKTKPKEKV KTKPEKFSLP KCSVQVGIKI SSVHKRLASE KRENPVKKVM 480
LASRSETSGK EAACESSTPS WASDHNYNAV KPEKPEKPTA LSPTLLSKSM KDDRRVEDRT 540
MAAVTIPKKA LPSASLVGRQ TSPRNLVPKK LPPYSNMAGA KPAIKKLPSG FKGTIPKRPW 600
PSATLSGTSA RQAGPTPMTA ASKKLPGSAA VVGVTRKPMS ANVPAASPAP GRLGPVSPAP 660
SQPNSQIRQN IRRSLKEILW KRVNDSDDLI MTENEVGKIA LHIEKEMFNL FQVTDNRYKS 720
KYRSIMFNLK DPKNQGLFHR VLREEISLAK LVRMKPEELV SKELSMWTEK PTKSVIESRT 780
KLLNESKKNT TKPETIPDME DSPPVSDSEE QQESVRAAPE KSAAPLLDVF SSMLKDTTSQ 840
HRAHLFDLNC KICTGQVPSS EDEPAPKKQK LSASSKKEDF KPRHDSSPPN AVPNTADEGI 900
ADTLPENASE PDPESTSSLN QERKCFPESP GDSHPEPSSL GGLSPSSASG GSGVVTTVTM 960
SGRDPRTALS GSCTVTASMA AHLDNSQASE TKLDMIKPAL TSAVVPKSIL AKPSSSPDPR 1020
YLSVPPSPSI SESRSPPEGD TTLFLSRLNT IWKGFINMQS VAKFVTKAYP VSGCLDYLSE 1080
DLPDTIHIGG RIAPKTVWDY VGKLKSSVSK ELCLIRFHPA TEEEEVAYIS LYSYFSSRGR 1140
FGVVANNNRH VKDLYLIPLS AKDPVPSKLL PFEGPGLESP RPNIILGLVI CQKVKRPSSA 1200
GELDKTDEKR TRLQQEELET SVYPKVTAAL PSEKKPPKYS VHSIDTAATS TTPPGSPPPP 1260
PPLPEPPVLK ILSSLKPGST STVTAPTTAA ITTTASPVTA ATSKTASPLE HILQTLFGKK 1320
KSFEPSGKES VGSTLSPHQD SKAKGEDTMS AAPLLDPIVQ QFGQFSKDKA LEEEEEDDRP 1380
YDPEEEYNPD RAFHTLLAEP GRPHDVQSVS ETAEREEVAY DPEDETILEE AKVTIDDLPN 1440
RMCMKVSATE RPADFTTDAS SASLVEQQKM LEELNKQIEE QKRQLEEQEE ALRQQRAAVG 1500
VSMAHFSVSD ALMSPPPKSS LGKTELFSQE QQAPDPSQGA PNTNHNLDSR QSRDPRQARR 1560
LAAENTENES LPRAPTGSTP GPQGTLPARE TPAGTAVVQG PGLAAEAKES MAVPWAPGEN 1620
AVLRPEHDIQ KCEHPGNPVS LPLDTSHLPT AGDGAARPAP PRRVLLPTPP STTFPPSFPL 1680
QPKAQNFSSG SREPFSGPTF MSQETSLGSS QYEDPRGAQS AGKNDSPVAD MEDSREPQPR 1740
PGESTTSFPQ PGQRGGGPQP QFPGQREPAP RTFGMSGHHG PSFPGPRGPV PPYSEENLVP 1800
NSDGPRGPPP ARFGAQKPPI PSLFSGQHGP PPYGDNRGLS PSYLGGPRGG APAQFEDRKD 1860
PHGEKREFQD TPYNEMTGAP AQCEGPDQAQ FMGNRAPFQF GGQRRPLLTQ MKGPRGGPPP 1920
SQFGAQRGPP PGHFVGPRGP HPSQFENSRG THPGQFEGAR GQAPGFMPGP RGIQPQQFEE 1980
QRVNSPPRFA GQRASAPLPY GGPRGPAPFP EKNEQPPSRF HFQGPSSQPV KPPPRPLLEL 2040
PSHPPQHRKD RWDEAGPATA LPSSAGPGQG HEADGQWATS EFREGKGHEY RSPAFEGRQR 2100
ERFEAGSKEK PLDEPEAQGL ESRQGRAFED RRRERERGRN WSRERDWERS RDWDRHREWD 2160
KGRDRSSNRD RERDNDRAKE WDRSRERSRN RDRDRERRRD RDRSRSRDRD RDRERARDRD 2220
RDRGRDRKDR SKSRESPRDQ KPEARTSEGG PAAAQA 2256 |
Gene Ontology | |
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Pfam | |
SMART | |
PROSITE | |
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