CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008846
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Atrophin-1 
Protein Synonyms/Alias
 Dentatorubral-pallidoluysian atrophy protein 
Gene Name
 ATN1 
Gene Synonyms/Alias
 D12S755E; DRPLA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
46STSSSDGKAEKSRQTacetylation[1]
641PGPPPYGKRAPSPGAacetylation[2]
947RDLRDRLKPGFEVKPubiquitination[3, 4]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats. 
Sequence Annotation
 REGION 517 567 Involved in binding BAIAP2.
 REGION 879 894 Required for interaction with FAT1.
 MOTIF 16 32 Nuclear localization signal.
 MOTIF 1033 1041 Nuclear export signal.
 MOD_RES 34 34 Phosphoserine.
 MOD_RES 77 77 Phosphoserine.
 MOD_RES 79 79 Phosphoserine.
 MOD_RES 101 101 Phosphoserine.
 MOD_RES 103 103 Phosphoserine.
 MOD_RES 107 107 Phosphoserine.
 MOD_RES 641 641 N6-acetyllysine.
 MOD_RES 653 653 Phosphothreonine.
 MOD_RES 661 661 Phosphoserine.
 MOD_RES 739 739 Phosphoserine; by MAPK8.
 MOD_RES 746 746 Phosphoserine.
 MOD_RES 748 748 Phosphoserine.  
Keyword
 Acetylation; Cell junction; Complete proteome; Cytoplasm; Epilepsy; Neurodegeneration; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Triplet repeat expansion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1190 AA 
Protein Sequence
MKTRQNKDSM SMRSGRKKEA PGPREELRSR GRASPGGVST SSSDGKAEKS RQTAKKARVE 60
EASTPKVNKQ GRSEEISESE SEETNAPKKT KTEQELPRPQ SPSDLDSLDG RSLNDDGSSD 120
PRDIDQDNRS TSPSIYSPGS VENDSDSSSG LSQGPARPYH PPPLFPPSPQ PPDSTPRQPE 180
ASFEPHPSVT PTGYHAPMEP PTSRMFQAPP GAPPPHPQLY PGGTGGVLSG PPMGPKGGGA 240
ASSVGGPNGG KQHPPPTTPI SVSSSGASGA PPTKPPTTPV GGGNLPSAPP PANFPHVTPN 300
LPPPPALRPL NNASASPPGL GAQPLPGHLP SPHAMGQGMG GLPPGPEKGP TLAPSPHSLP 360
PASSSAPAPP MRFPYSSSSS SSAAASSSSS SSSSSASPFP ASQALPSYPH SFPPPTSLSV 420
SNQPPKYTQP SLPSQAVWSQ GPPPPPPYGR LLANSNAHPG PFPPSTGAQS TAHPPVSTHH 480
HHHQQQQQQQ QQQQQQQQQQ QQHHGNSGPP PPGAFPHPLE GGSSHHAHPY AMSPSLGSLR 540
PYPPGPAHLP PPHSQVSYSQ AGPNGPPVSS SSNSSSSTSQ GSYPCSHPSP SQGPQGAPYP 600
FPPVPTVTTS SATLSTVIAT VASSPAGYKT ASPPGPPPYG KRAPSPGAYK TATPPGYKPG 660
SPPSFRTGTP PGYRGTSPPA GPGTFKPGSP TVGPGPLPPA GPSGLPSLPP PPAAPASGPP 720
LSATQIKQEP AEEYETPESP VPPARSPSPP PKVVDVPSHA SQSARFNKHL DRGFNSCARS 780
DLYFVPLEGS KLAKKRADLV EKVRREAEQR AREEKERERE REREKERERE KERELERSVK 840
LAQEGRAPVE CPSLGPVPHR PPFEPGSAVA TVPPYLGPDT PALRTLSEYA RPHVMSPGNR 900
NHPFYVPLGA VDPGLLGYNV PALYSSDPAA REREREARER DLRDRLKPGF EVKPSELEPL 960
HGVPGPGLDP FPRHGGLALQ PGPPGLHPFP FHPSLGPLER ERLALAAGPA LRPDMSYAER 1020
LAAERQHAER VAALGNDPLA RLQMLNVTPH HHQHSHIHSH LHLHQQDAIH AASASVHPLI 1080
DPLASGSHLT RIPYPAGTLP NPLLPHPLHE NEVLRHQLFA APYRDLPASL SAPMSAAHQL 1140
QAMHAQSAEL QRLALEQQQW LHAHHPLHSV PLPAQEDYYS HLKKESDKPL 1190 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0016363; C:nuclear matrix; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0007417; P:central nervous system development; TAS:ProtInc.
 GO:0030011; P:maintenance of cell polarity; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0051402; P:neuron apoptotic process; IDA:UniProtKB.
 GO:0009404; P:toxin metabolic process; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR017993; Atrophin-1.
 IPR002951; Atrophin-like. 
Pfam
 PF03154; Atrophin-1 
SMART
  
PROSITE
  
PRINTS
 PR01222; ATROPHIN.