CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040673
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Anaphase-promoting complex subunit 7 
Protein Synonyms/Alias
  
Gene Name
 ANAPC7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58EDPVTQEKAKTLLDKubiquitination[1, 2]
60PVTQEKAKTLLDKALubiquitination[2]
65KAKTLLDKALTQRPDacetylation[3]
65KAKTLLDKALTQRPDubiquitination[2, 3, 4, 5, 6]
75TQRPDYIKAVVKKAEubiquitination[2, 3, 4, 5, 6]
80YIKAVVKKAELLSREubiquitination[2, 3]
89ELLSREQKYEDGIALubiquitination[1, 2, 3, 4, 5]
149KSLEGMQKMEKEESPubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 164 AA 
Protein Sequence
MSSRVLLFSG LIECYLASNS IREAMVMANN VYKTLGANAQ TLTLLATVCL EDPVTQEKAK 60
TLLDKALTQR PDYIKAVVKK AELLSREQKY EDGIALLRNA LANQSDCVLH RILGDFLVAV 120
NEYQEAMDQY SIALSLDPND QKSLEGMQKM EKEESPTDAT QEED 164 
Gene Ontology
  
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF07719; TPR_2 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS