CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044155
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mitochondrial 2-oxoglutarate/malate carrier protein 
Protein Synonyms/Alias
  
Gene Name
 SLC25A11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15GAGGIDGKPRTSPKMubiquitination[1, 2, 3]
46QLSGEGAKTREYKTSubiquitination[3, 4, 5]
51GAKTREYKTSFHALTubiquitination[4]
62HALTSILKAEGLRGIubiquitination[4]
151ADQRRGYKNVFNALIubiquitination[4]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 296 AA 
Protein Sequence
MAATASAGAG GIDGKPRTSP KMGATVFVQP LDLVKNRMQL SGEGAKTREY KTSFHALTSI 60
LKAEGLRGIY TGLSAGLLRQ ATYTTTRLGI YTVLFERLTG ADGTPPGFLL KAVIGMTAGA 120
TGAFVGTPAE VALIRMTADG RLPADQRRGY KNVFNALIRI TREEGVLTLW RGCIPTMARA 180
VVVNAAQLAS YSQSKQFLLD SGYFSDNILC HFCASMISGL VTTAASMPVD IAKTRIQNMR 240
MIDGKPEYKN GLDVLFKVVR YEGFFSLWKG FTPYYARLGP HTVLTFIFLE QMNKAY 296 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS