CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Forkhead box O3a (Predicted) 
Protein Synonyms/Alias
 Protein Foxo3 
Gene Name
 Foxo3 
Gene Synonyms/Alias
 Foxo3a_predicted; rCG_58542 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
241IINPDGGKSGKAPRRacetylation[1]
258VSMDNSNKYTKSRGRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 672 AA 
Protein Sequence
MAEAPASPVP LSPLEVELDP EFEPQSRPRS CTWPLQRPEL QASPAKPSGE TAADSMIPEE 60
DDDEDDEDSG GRGSSAMVIG GGVSSALGSG LLLEDSARLL SPGGQDLGTG PASSAGALSG 120
GTQTQLQPQQ PLPPPQPGAA GGSGQPRKCS SRRNAWGNLS YADLITRAIE SSPDKRLTLS 180
QIYEWMVRCV PYFKDKGDSN SSAGWKNSIR HNLSLHSRFM RVQNEGTGKS SWWIINPDGG 240
KSGKAPRRRA VSMDNSNKYT KSRGRAAKKK AALQAAPESA DDSPSQLSKW PGSPTSRSSD 300
ELDAWTDFRS RTNSNASTVS GRLSPILAST ELDDVQDDDG PLSPMLYSSS ASLSPSVSKP 360
CTVELPRLTD MAGTMNLNDG LAENLMDDLL DNIALPPSQA SPPGGLMQRS SSFPYTAKSS 420
GLGSPTSSFN STVFGPASLN SLRQSPMQTI QENRPATFSS VSHYGNQTLQ DLLTSDSLSH 480
SDVMMTQSDP LMSQASTAVS AQNARRNVML RNDPMMSFAA QPTQGSLVNQ NLLHHQHQTQ 540
GALGGSRALS NSVSNMGLSD SSSLGSAKHQ QQSPVSQSMQ TLSDSLSGSS LYSASANLPV 600
MGHDKFPSDL DLDMFNGSLE CDMESIIRSE LMDADGLDFN FDSLISTQNV VGLNVGNFTG 660
AKQASSQSWV PG 672 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0019901; F:protein kinase binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0001547; P:antral ovarian follicle growth; IBA:RefGenome.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; IEA:Compara.
 GO:0009790; P:embryo development; IBA:RefGenome.
 GO:0042593; P:glucose homeostasis; IBA:RefGenome.
 GO:0006917; P:induction of apoptosis; IBA:RefGenome.
 GO:0001544; P:initiation of primordial ovarian follicle growth; IBA:RefGenome.
 GO:0008286; P:insulin receptor signaling pathway; IBA:RefGenome.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0001556; P:oocyte maturation; IBA:RefGenome.
 GO:0001542; P:ovulation from ovarian follicle; IBA:RefGenome.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IBA:RefGenome.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0042127; P:regulation of cell proliferation; IBA:RefGenome.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0006417; P:regulation of translation; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IBA:RefGenome.
 GO:0009888; P:tissue development; IBA:RefGenome. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH 
PROSITE
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 
PRINTS
 PR00053; FORKHEAD.