CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 680 
Protein Synonyms/Alias
  
Gene Name
 ZNF680 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
127LQLRISCKSVDESKVubiquitination[1]
136VDESKVFKEGYNELNubiquitination[2]
348KKIHTGEKPYKCEECubiquitination[1]
497YKCEECGKAFNRSSHubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 13 84 KRAB.
 ZN_FING 182 204 C2H2-type 1.
 ZN_FING 210 232 C2H2-type 2.
 ZN_FING 238 260 C2H2-type 3.
 ZN_FING 266 288 C2H2-type 4.
 ZN_FING 294 316 C2H2-type 5.
 ZN_FING 322 344 C2H2-type 6.
 ZN_FING 350 372 C2H2-type 7.
 ZN_FING 378 400 C2H2-type 8.
 ZN_FING 406 428 C2H2-type 9.
 ZN_FING 434 456 C2H2-type 10.
 ZN_FING 462 484 C2H2-type 11.
 ZN_FING 490 512 C2H2-type 12.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 530 AA 
Protein Sequence
MPGPPGSLEM GPLTFRDVAI EFSLEEWQCL DTAQRNLYRK VMFENYRNLV FLGIAVSKPH 60
LITCLEQGKE PWNRKRQEMV AKPPVIYSHF TEDLWPEHSI KDSFQKVILR GYGKCGHENL 120
QLRISCKSVD ESKVFKEGYN ELNQCLRTTQ SKIFQCDKYV KVFHKFSNSN SHKKRNTGKK 180
VFKCKECGKS FCMLSHLTQH IRIHTRENSY KCEECGKVLN WFSELIKHKG IHMGEKPYKC 240
EECGKAFNQS STLIKHKKIH IEEKPFKCEE CGKAFSLFSI LSKHKIIHTG DKPYKCDECH 300
KAFNWFATLT NHKRIHTGEK PFKCEECGKD FNQFSNLTKH KKIHTGEKPY KCEECGKAFN 360
QFANLTRHKK IHTGEKSYKC EECGKAFIQS SNLTEHMRIH TGEKPYKCEE CGKAFNGCSS 420
LTRHKRIHTR ENTYKCEECG KGFTLFSTLT NHKVIHTGEK SYKCDECGNV FNWPATLANH 480
KRIHAREKPY KCEECGKAFN RSSHLTRHKK IHTGEKLYKP EKCDNNFDNT 530 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB
 PF00096; zf-C2H2 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS