UniProt Accession

 COTL1_RAT; B0BNA5 

Genbank Protein ID

 CH473972; CH473972; BC158746 

Genbank Nucleotide ID

 EDL92684.1; EDL92686.1; AAI58747.1 

Protein Name

 Coactosin-like protein 

Protein Synonyms/Alias

  

Gene Name

 Cotl1 

Gene Synonyms/Alias

 Clp 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MATKIDKEACR	acetylation	[1]
130	DFIRSELKKAGGANY	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity). 

Sequence Annotation

 DOMAIN 2 130 ADF-H.
 REGION 66 75 Flexible and important for F-actin
 MOD_RES 102 102 N6-acetyllysine (By similarity).
 MOD_RES 141 141 Phosphoserine (By similarity).  

Keyword

 Acetylation; Actin-binding; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0050832; P:defense response to fungus; IEA:Compara. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin. 

Pfam

 PF00241; Cofilin_ADF 

SMART

 SM00102; ADF 

PROSITE

 PS51263; ADF_H 

PRINTS