[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
Functional Description
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.
Sequence Annotation
REPEAT 279 291 1-1. REPEAT 296 308 1-2. REPEAT 315 327 1-3. REPEAT 334 346 1-4. REPEAT 349 359 2-1. REPEAT 368 378 2-2. REPEAT 382 392 2-3. REPEAT 396 406 2-4. REGION 277 410 P domain (Extended arm) (By similarity). REGION 279 346 4 X approximate repeats. REGION 349 406 4 X approximate repeats. REGION 504 591 Sufficient to mediate interaction with METAL 75 75 Calcium; via carbonyl oxygen (By METAL 118 118 Calcium; via carbonyl oxygen (By METAL 437 437 Calcium (By similarity). BINDING 165 165 Carbohydrate (By similarity). BINDING 167 167 Carbohydrate (By similarity). BINDING 186 186 Carbohydrate (By similarity). BINDING 217 217 Carbohydrate (By similarity). MOD_RES 138 138 N6-acetyllysine (By similarity). MOD_RES 553 553 Phosphoserine (By similarity). MOD_RES 561 561 Phosphothreonine (By similarity). MOD_RES 563 563 Phosphoserine; by MAPK3. MOD_RES 569 569 Phosphoserine (By similarity). MOD_RES 582 582 Phosphoserine (By similarity). LIPID 503 503 S-palmitoyl cysteine (By similarity). LIPID 504 504 S-palmitoyl cysteine (By similarity). DISULFID 161 195 By similarity. DISULFID 361 367 By similarity.