UniProt Accession

 PP2BA_MOUSE; P63328; P12816; P20652; Q3UCU1; Q64135 

Genbank Protein ID

 J05479; AK146387; AK150393; J04134; S78668 

Genbank Nucleotide ID

 AAA37359.1; BAE27131.1; BAE29521.1; AAA37432.1; AAB34675.1 

Protein Name

 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 

Protein Synonyms/Alias

 CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform 

Gene Name

 Ppp3ca 

Gene Synonyms/Alias

 Calna 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
10	EPKAIDPKLSTTDRV	ubiquitination	[1]
32	PSHRLTAKEVFDNDG	ubiquitination	[1]
142	ALKILYPKTLFLLRG	ubiquitination	[1]
466	KGFSPQHKITSFEEA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L and HSPB1 (By similarity). Dephosphorylates SSH1. 

Sequence Annotation

 REGION 1 301 Catalytic.
 REGION 247 253 Calcineurin B binding-site 1 (Potential).
 REGION 296 301 Calcineurin B binding-site 2 (Potential).
 REGION 392 414 Calmodulin-binding (Potential).
 REGION 465 487 Inhibitory domain.
 ACT_SITE 151 151 Proton donor (By similarity).
 METAL 90 90 Iron (By similarity).
 METAL 92 92 Iron (By similarity).
 METAL 118 118 Iron (By similarity).
 METAL 118 118 Zinc (By similarity).
 METAL 150 150 Zinc (By similarity).
 METAL 199 199 Zinc (By similarity).
 METAL 281 281 Zinc (By similarity).
 MOD_RES 224 224 Nitrated tyrosine.
 MOD_RES 469 469 Phosphoserine.  

Keyword

 Alternative splicing; Calmodulin-binding; Complete proteome; Direct protein sequencing; Hydrolase; Iron; Metal-binding; Nitration; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 521 AA 

Protein Sequence

Gene Ontology

 GO:0005955; C:calcineurin complex; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0033192; F:calmodulin-dependent protein phosphatase activity; ISS:UniProtKB.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0033173; P:calcineurin-NFAT signaling cascade; IDA:MGI.
 GO:0006816; P:calcium ion transport; IMP:MGI.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:0033555; P:multicellular organismal response to stress; IDA:MGI.
 GO:0046676; P:negative regulation of insulin secretion; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0006470; P:protein dephosphorylation; IMP:MGI.
 GO:0006606; P:protein import into nucleus; IDA:MGI.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IGI:MGI.
 GO:0050804; P:regulation of synaptic transmission; IMP:MGI.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0051592; P:response to calcium ion; ISS:UniProtKB.
 GO:0048741; P:skeletal muscle fiber development; IMP:MGI.
 GO:0014883; P:transition between fast and slow fiber; IDA:MGI. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.