UniProt Accession

 CD3D_HUMAN; P04234; A8MVP6 

Genbank Protein ID

 X03934; M12727; M12726; CD014058; AP001582; BC039035; BC070321; X01451 

Genbank Nucleotide ID

 CAA27573.1; AAA51792.1; AAA51792.1; AAH39035.1; AAH70321.1; CAA25683.1 

Protein Name

 T-cell surface glycoprotein CD3 delta chain 

Protein Synonyms/Alias

 T-cell receptor T3 delta chain; CD3d 

Gene Name

 CD3D 

Gene Synonyms/Alias

 T3D 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	ITRLDLGKRILDPRG	ubiquitination	[1]
80	CNGTDIYKDKESTVQ	ubiquitination	[1, 2]
82	GTDIYKDKESTVQVH	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 The CD3 complex mediates signal transduction. 

Sequence Annotation

 DOMAIN 138 166 ITAM.
 MOD_RES 149 149 Phosphotyrosine.
 MOD_RES 160 160 Phosphotyrosine.
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 DISULFID 37 73  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; SCID; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0042105; C:alpha-beta T cell receptor complex; IEA:Compara.
 GO:0005737; C:cytoplasm; NAS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042101; C:T cell receptor complex; NAS:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0004888; F:transmembrane signaling receptor activity; IC:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045059; P:positive thymic T cell selection; ISS:UniProtKB.
 GO:0031295; P:T cell costimulation; TAS:Reactome.
 GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR015485; CD3_delta.
 IPR015484; CD3_gsu/dsu.
 IPR013783; Ig-like_fold.
 IPR003110; Phos_immunorcpt_sig_ITAM. 

Pfam

 PF02189; ITAM 

SMART

 SM00077; ITAM 

PROSITE

 PS51055; ITAM_1 

PRINTS