CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027878
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aldo-keto reductase a 
Protein Synonyms/Alias
 MCG114465, isoform CRA_a; Protein Akr1c12 
Gene Name
 Akr1c12 
Gene Synonyms/Alias
 Akra; mCG_114465 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
4****MSSKQHYVKLNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 ACT_SITE 55 55 Proton donor (By similarity).  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 323 AA 
Protein Sequence
MSSKQHYVKL NDGHLIPALG FGTYKPKEVP KSKSLEAACL ALDVGYRHVD TAYAYQVEEE 60
IGQAIQSKIK AGVVKREDLF ITTKLWCGCF RPELVKPALE KSLKSLQLDY VDLYLIHYPV 120
PMKPGDNESP LDENGKFLLD TVDFCDTWER LEECKDAGLV KSIGVSNFNH RQLERILNKP 180
GLKYKPVCNQ VECHLYLNQS KLLDYCKSKD IVLVAYGALG TQRYKEWVDQ NSPVLLNDPV 240
LCDVAKRNKR SPALIALRYL FQRGIVPLAQ SFKENEMREN LQVFEFQLSP EDMKTLDGLN 300
KNFRYLPAEF LADHPEYPFS EEY 323 
Gene Ontology
 GO:0004033; F:aldo-keto reductase (NADP) activity; ISS:MGI.
 GO:0006805; P:xenobiotic metabolic process; TAS:MGI. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2 
PRINTS
 PR00069; ALDKETRDTASE.