CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium-dependent multivitamin transporter 
Protein Synonyms/Alias
 Na(+)-dependent multivitamin transporter; Solute carrier family 5 member 6 
Gene Name
 SLC5A6 
Gene Synonyms/Alias
 SMVT 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
579LLPLSCQKRLHCRSYubiquitination[1, 2, 3, 4]
599DTGLFPEKPRNGVLGubiquitination[1, 2, 3, 4, 5, 6, 7]
611VLGDSRDKEAMALDGubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Transports pantothenate, biotin and lipoate in the presence of sodium. 
Sequence Annotation
 CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
 CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).
 CARBOHYD 498 498 N-linked (GlcNAc...) (Potential).  
Keyword
 Biotin; Complete proteome; Glycoprotein; Ion transport; Membrane; Polymorphism; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 635 AA 
Protein Sequence
MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG WGRHTVGELL 60
MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW FLGCCYFLGL LIPAHIFIPV 120
FYRLHLTSAY EYLELRFNKT VRVCGTVTFI FQMVIYMGVV LYAPSLALNA VTGFDLWLSV 180
LALGIVCTVY TALGGLKAVI WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR 240
ISGFELDPDP FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF 300
QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG LPGLFIACLF 360
SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR GLAFGYGLLC LGMAYISSQM 420
GPVLQAAISI FGMVGGPLLG LFCLGMFFPC ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG 480
SSMPPSPSNG SSFSLPTNLT VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV 540
VGLIVSLLTG RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP 600
RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL 635 
Gene Ontology
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0012506; C:vesicle membrane; IEA:Compara.
 GO:0008523; F:sodium-dependent multivitamin transmembrane transporter activity; TAS:ProtInc.
 GO:0006768; P:biotin metabolic process; TAS:Reactome.
 GO:0015878; P:biotin transport; IEA:Compara.
 GO:0015939; P:pantothenate metabolic process; TAS:Reactome.
 GO:0015887; P:pantothenate transmembrane transport; IEA:Compara. 
Interpro
 IPR001734; Na/solute_symporter.
 IPR018212; Na/solute_symporter_CS.
 IPR019900; Na/solute_symporter_subgr. 
Pfam
 PF00474; SSF 
SMART
  
PROSITE
 PS00456; NA_SOLUT_SYMP_1
 PS00457; NA_SOLUT_SYMP_2
 PS50283; NA_SOLUT_SYMP_3 
PRINTS