CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039035
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 GMP reductase 
Protein Synonyms/Alias
  
Gene Name
 Gmpr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
13ADLKLDFKDVLLRPKacetylation[1]
291EYRASEGKTVEVPYKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; NADP; Oxidoreductase; Potassium; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 345 AA 
Protein Sequence
MPRIDADLKL DFKDVLLRPK RSSLKSRSEV DLERTFTFRN SKQTYSGIPV IVANMDTVGT 60
FEMAVVMSQH AMFTAIHKHY SLDDWKHFAE NHPECLQHVA VSSGSGQNDL EKMSLILEAV 120
PQVKFICLDV ANGYSEHFVE FVKLVRSKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV 180
GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM 240
LGGMFSGHTE CAGEVIERNG QKLKLFYGMS SDTAMKKHAG GVAEYRASEG KTVEVPYKGD 300
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFG 345 
Gene Ontology
 GO:0003920; F:GMP reductase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0009117; P:nucleotide metabolic process; IEA:InterPro. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR005993; GMP_reduct1.
 IPR015875; IMP_DH/GMP_Rdtase_CS.
 IPR001093; IMP_DH_GMPRt. 
Pfam
 PF00478; IMPDH 
SMART
  
PROSITE
 PS00487; IMP_DH_GMP_RED 
PRINTS