CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009605
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein subunit beta-5 
Protein Synonyms/Alias
 Gbeta5; Transducin beta chain 5 
Gene Name
 Gnb5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
32KLEEERAKLHDVELHubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. 
Sequence Annotation
 REPEAT 61 100 WD 1.
 REPEAT 103 142 WD 2.
 REPEAT 151 192 WD 3.
 REPEAT 194 236 WD 4.
 REPEAT 237 276 WD 5.
 REPEAT 278 320 WD 6.
 REPEAT 323 352 WD 7.  
Keyword
 Complete proteome; Reference proteome; Repeat; Transducer; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 353 AA 
Protein Sequence
MATDGLHENE TLASLKSEAE SLKGKLEEER AKLHDVELHQ VAERVEALGQ FVMKTRRTLK 60
GHGNKVLCMD WCKDKRRIVS SSQDGKVIVW DSFTTNKEHA VTMPCTWVMA CAYAPSGCAI 120
ACGGLDNKCS VYPLTFDKNE NMAAKKKSVA MHTNYLSACS FTNSDMQILT ASGDGTCALW 180
DVESGQLLQS FHGHGADVLC LDLAPSETGN TFVSGGCDKK AMVWDMRSGQ CVQAFETHES 240
DVNSVRYYPS GDAFASGSDD ATCRLYDLRA DREVAIYSKE SIIFGASSVD FSLSGRLLFA 300
GYNDYTINVW DVLKGSRVSI LFGHENRVST LRVSPDGTAF CSGSWDHTLR VWA 353 
Gene Ontology
 GO:0044297; C:cell body; IDA:RGD.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005834; C:heterotrimeric G-protein complex; TAS:RGD.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:RGD. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR001632; Gprotein_B.
 IPR016346; Guanine_nucleotide-bd_bsu.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00319; GPROTEINB.
 PR00320; GPROTEINBRPT.