CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038765
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 T-complex protein 1 subunit zeta 
Protein Synonyms/Alias
  
Gene Name
 Cct6a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***MAAVKTLNPKAEacetylation[1, 2]
10AVKTLNPKAEVARAQubiquitination[3]
127TEGFEAAKEKALQFLacetylation[4]
127TEGFEAAKEKALQFLubiquitination[3]
129GFEAAKEKALQFLEQacetylation[2]
129GFEAAKEKALQFLEQsuccinylation[2]
129GFEAAKEKALQFLEQubiquitination[3]
138LQFLEQVKVSKEMDRubiquitination[3]
199EIMEMKHKSETDTSLacetylation[2]
199EIMEMKHKSETDTSLubiquitination[3]
251VNSGFFYKSAEEREKacetylation[1]
251VNSGFFYKSAEEREKubiquitination[3]
287KVCGDSDKGFVVINQacetylation[1, 2, 4, 5]
295GFVVINQKGIDPFSLubiquitination[3]
307FSLDALAKEGIVALRacetylation[1]
307FSLDALAKEGIVALRubiquitination[3]
365EKFTFIEKCNNPRSVacetylation[1, 2, 4]
365EKFTFIEKCNNPRSVubiquitination[3]
381LLVKGPNKHTLTQIKacetylation[2]
531RAGMSSLKG******ubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 532 AA 
Protein Sequence
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 60
NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT 120
EGFEAAKEKA LQFLEQVKVS KEMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIR 180
KKDEPIDLFM VEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVENAYI LTCNVSLEYE 240
KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKKK VCGDSDKGFV VINQKGIDPF 300
SLDALAKEGI VALRRAKRRN MERLTLACGG IALNSFDDLN PDCLGHAELV YEYTLGEEKF 360
TFIEKCNNPR SVTLLVKGPN KHTLTQIKDA IRDGLRAVKN AIDDGCILWN SGPLEEQSVL 420
LIAEPSPQPP GNFLKLEILF IYSGLTLNSQ VLAQNSGFDL QETLVKVQAE HSESGQLVGV 480
DLSTGEPMVA AEMGVWDNYC VKKQLLHSCT VIATNILLVD EIMRAGMSSL KG 532 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IDA:MGI.
 GO:0044297; C:cell body; IDA:MGI.
 GO:0005832; C:chaperonin-containing T-complex; IDA:MGI.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0002199; C:zona pellucida receptor complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0007339; P:binding of sperm to zona pellucida; IDA:MGI.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012722; Chap_CCT_zeta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.