CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037339
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tolloid-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 TLL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
278GQEYNFLKMEPGEVNubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Hydrolase; Metal-binding; Protease; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1036 AA 
Protein Sequence
MGLGTLSPRM LVWLVASGIV FYGELWVCAG LDYDYTFDGN EEDKTETIDY KDPCKAAVFW 60
GDIALDDEDL NIFQIDRTID LTQNPFGNLG HTTGGLGDHA MSKKRGALYQ LIDRIRRIGF 120
GLEQNNTVKG KVPLQFSGQN EKNRVPRAAT SRTERIWPGG VIPYVIGGNF TGSQRAMFKQ 180
AMRHWEKHTC VTFIERSDEE SYIVFTYRPC GCCSYVGRRG NGPQAISIGK NCDKFGIVVH 240
ELGHVIGFWH EHTRPDRDNH VTIIRENIQP GQEYNFLKME PGEVNSLGER YDFDSIMHYA 300
RNTFSRGMFL DTILPSRDDN GIRPAIGQRT RLSKGDIAQA RKLYRCPACG ETLQESNGNL 360
SSPGFPNGYP SYTHCIWRVS VTPGEKIVLN FTTMDLYKSS LCWYDYIEVR DGYWRKSPLL 420
GRFCGDKLPE VLTSTDSRMW IEFRSSSNWV GKGFAAVYEA ICGGEIRKNE GQIQSPNYPD 480
DYRPMKECVW KITVSESYHV GLTFQSFEQE HQENPGIASK ARESLILIWK PIERHDNCAY 540
DYLEVRDGTS ENSPLIGRFC GYDKPEDIRS TSNTLWMKFV SDGTVNKAGF AANFFKEEDE 600
CAKPDRGGCE QRCLNTLGSY QCACEPGYEL GPDRRSCEAA CGGLLTKLNG TITTPGWPKE 660
YPPNKNCVWQ VVAPTQYRIS VKFEFFELEG NEVCKYDYVE IWSGLSSESK LHGKFCGAEV 720
PEVITSQFNN MRIEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQHECVN TMGSYMCQCR 780
NGFVLHDNKH DCKEAECEQK IHSPSGLITS PNWPDKYPSR KECTWEISAT PGHRIKLAFS 840
EFEIEQHQEC AYDHLEVFDG ETEKSPILGR LCGNKIPDPL VATGNKMFVR FVSDASVQRK 900
GFQATHSTEC GGRLKAESKP RDLYSHAQFG DNNYPGQVDC EWLLVSERGS RLELSFQTFE 960
VEEEADCGYD YVELFDGLDS TAVGLGRFCG SGPPEEIYSI GDSVLIHFHT DDTINKKGFH 1020
IRYKSIRYPD TTHTKK 1036 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR015446; BMP_1/tolloid-like.
 IPR000859; CUB_dom.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001506; Peptidase_M12A.
 IPR006026; Peptidase_Metallo. 
Pfam
 PF01400; Astacin
 PF00431; CUB
 PF07645; EGF_CA 
SMART
 SM00042; CUB
 SM00179; EGF_CA
 SM00235; ZnMc 
PROSITE
 PS00010; ASX_HYDROXYL
 PS01180; CUB
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA 
PRINTS
 PR00480; ASTACIN.