CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032394
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alstrom syndrome protein 1 
Protein Synonyms/Alias
  
Gene Name
 ALMS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2515GRTTDLSKGLQSPRGubiquitination[1, 2, 3]
2526SPRGMGCKPEAVCSHubiquitination[2, 3]
2582NPSSCRAKHVNLSASubiquitination[2, 3]
2606VWNSLQLKSHSPFQNubiquitination[2, 3]
2620NFIPDEFKISKGLRMubiquitination[2, 3]
2623PDEFKISKGLRMPFDubiquitination[2]
2632LRMPFDEKMDPWLSEubiquitination[2]
2681FSSHRHSKCISNSSVubiquitination[2]
2740MHSNSQDKEVTILAEubiquitination[2]
2754EGRRQSQKLPVDFERubiquitination[2]
2767ERSFQEEKPLERSDFubiquitination[2]
2791RANCSNFKEIQISDNubiquitination[2]
2825SRLGVKEKNVTITPDubiquitination[2, 3, 4]
2849RELFEQSKAPRADDHubiquitination[2]
2859RADDHVRKHHSPSPQubiquitination[2]
2891RELFEQCKAPYVDHQubiquitination[2, 3]
3015LCPKTSSKLDSGTLDubiquitination[2]
3033HSLDAASKARMNSEFubiquitination[2]
3057RSLEPTSKLLTSKPVubiquitination[2]
3062TSKLLTSKPVAQDQEubiquitination[2, 3]
3143DRLPEKMKTPLSAFSubiquitination[2]
3152PLSAFSEKLSSDAVTubiquitination[2]
3226QPLLLPYKPSGSTKMubiquitination[2]
3232YKPSGSTKMYYVPQLubiquitination[2]
3387MKNLPDTKAITQKEEubiquitination[2]
3392DTKAITQKEEIHRKKubiquitination[2]
3460ICHESLGKSVFMRHSubiquitination[2]
3469VFMRHSWKDFFQHHPubiquitination[2]
3478FFQHHPDKHREHMCLubiquitination[2]
3494LPYQNMDKTKTDYTRubiquitination[2]
3521KEVMDTTKSQVRDYPubiquitination[2]
3542SDPQRDQKVTPEQTTubiquitination[2]
3561SLNELWNKYRERQRQubiquitination[2, 3]
3842QNVHMLNKGIQAGNLubiquitination[2]
3931NVESRSKKENVPNTCubiquitination[2]
3950SWFEPITKTRPWREPubiquitination[5]
4055NRMCPLPKRVFLAIQubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4125 AA 
Protein Sequence
MEPEDLPWPG ELEEEEEEEE EEEEEEEEAA AAAAANVDDV VVVEEVEEEA GRELDSDSHY 60
GPQHLESIDD EEDEEAKAWL QAHPGRILPP LSPPQHRYSE GERTSLEKKT ESWHCLPQEM 120
DSSQTLDTSQ TRFNVRTEDT EVTDFPSLEE GILTQSENQV KEPNRDLFCS PLLVIQDSFA 180
SPDLPLLTCL TQDQEFAPDS LFHQSELSFA PLRGIPDKSE DTEWSSRPSE VSEALFQATA 240
EVASDLASSR FSVSQHPLIG STAVGSQCPF LPSEQGNNEE TISSVDELKI PKDCDRYDDL 300
CSYMSWKTRK DTQWPENNLA DKDQVSVATS FDITDENIAT KRSDHFDAAR SYGQYWTQED 360
SSKQAETYLT KGLQGKVESD VITLDGLNEN AVVCSERVAE LQRKPTRESE YHSSDLRMLR 420
MSPDTVPKAP KHLKAGDTSK GGIAKVTQSN LKSGITTTPV DSDIGSHLSL SLEDLSQLAV 480
SSLETTTGQH TDTLNQKTLA DTHLTEETLK VTAIPEPADQ KTATPTVLSS SHSHRGKPSI 540
FYQQGLPDSH LTEEALKVSA APGLADQTTG MSTLTSTSYS HREKPGTFYQ QELPESNLTE 600
EPLEVSAAPG PVEQKTGIPT VSSTSHSHVE DLLFFYRQTL PDGHLTDQAL KVSAVSGPAD 660
QKTGTATVLS TPHSHREKPG IFYQQEFADS HQTEETLTKV SATPGPADQK TEIPAVQSSS 720
YSQREKPSIL YPQDLADSHL PEEGLKVSAV AGPADQKTGL PTVPSSAYSH REKLLVFYQQ 780
ALLDSHLPEE ALKVSAVSGP ADGKTGTPAV TSTSSASSSL GEKPSAFYQQ TLPNSHLTEE 840
ALKVSIVPGP GDQKTGIPSA PSSFYSHREK PIIFSQQTLP DFLFPEEALK VSAVSVLAAQ 900
KTGTPTVSSN SHSHSEKSSV FYQQELPDSD LPRESLKMSA IPGLTDQKTV PTPTVPSGSF 960
SHREKPSIFY QQEWPDSYAT EKALKVSTGP GPADQKTEIP AVQSSSYPQR EKPSVLYPQV 1020
LSDSHLPEES LKVSAFPGPA DQMTDTPAVP STFYSQREKP GIFYQQTLPE SHLPKEALKI 1080
SVAPGLADQK TGTPTVTSTS YSQHREKPSI FHQQALPGTH IPEEAQKVSA VTGPGNQKTW 1140
IPRVLSTFYS QREKPGIFYQ QTLPGSHIPE EAQKVSPVLG PADQKTGTPT PTSASYSHTE 1200
KPGIFYQQVL PDNHPTEEAL KISVASEPVD QTTGTPAVTS TSYSQYREKP SIFYQQSLPS 1260
SHLTEEAKNV SAVPGPADQK TVIPILPSTF YSHTEKPGVF YQQVLPHSHP TEEALKISVA 1320
SEPVDQTTGT PTVTSTSYSQ HTEKPSIFYQ QSLPGSHLTE EAKNVSAVPG PGDRKTGIPT 1380
LPSTFYSHTE KPGSFYQQVL PHSHLPEEAL EVSVAPGPVD QTIGTPTVTS PSSSFGEKPI 1440
VIYKQAFPEG HLPEESLKVS VAPGPVGQTT GAPTITSPSY SQHRAKSGSF YQLALLGSQI 1500
PEEALRVSSA PGPADQTTGI PTITSTSYSF GEKPIVNYKQ AFPDGHLPEE ALKVSIVSGP 1560
TEKKTDIPAG PLGSSALGEK PITFYRQALL DSPLNKEVVK VSAAPGPADQ KTETLPVHST 1620
SYSNRGKPVI FYQQTLSDSH LPEEALKVPP VPGPDAQKTE TPSVSSSLYS YREKPIVFYQ 1680
QALPDSELTQ EALKVSAVPQ PADQKTGLST VTSSFYSHTE KPNISYQQEL PDSHLTEEAL 1740
KVSNVPGPAD QKTGVSTVTS TSYSHREKPI VSYQRELPHF TEAGLKILRV PGPADQKTGI 1800
NILPSNSYPQ REHSVISYEQ ELPDLTEVTL KAIGVPGPAD QKTGIQIASS SSYSNREKAS 1860
IFHQQELPDV TEEALNVFVV PGQGDRKTEI PTVPLSYYSR REKPSVISQQ ELPDSHLTEE 1920
ALKVSPVSIP AEQKTGIPIG LSSSYSHSHK EKLKISTVHI PDDQKTEFPA ATLSSYSQIE 1980
KPKISTVIGP NDQKTPSQTA FHSSYSQTVK PNILFQQQLP DRDQSKGILK ISAVPELTDV 2040
NTGKPVSLSS SYFHREKSNI FSPQELPGSH VTEDVLKVST IPGPAGQKTV LPTALPSSFS 2100
HREKPDIFYQ KDLPDRHLTE DALKISSALG QADQITGLQT VPSGTYSHGE NHKLVSEHVQ 2160
RLIDNLNSSD SSVSSNNVLL NSQADDRVVI NKPESAGFRD VGSEEIQDAE NSAKTLKEIR 2220
TLLMEAENMA LKRCNFPAPL ARFRDISDIS FIQSKKVVCF KEPSSTGVSN GDLLHRQPFT 2280
EESPSSRCIQ KDIGTQTNLK CRRGIENWEF ISSTTVRSPL QEAESKVSMA LEETLRQYQA 2340
AKSVMRSEPE GCSGTIGNKI IIPMMTVIKS DSSSDASDGN GSCSWDSNLP ESLESVSDVL 2400
LNFFPYVSPK TSITDSREEE GVSESEDGGG SSVDSLAAHV KNLLQCESSL NHAKEILRNA 2460
EEEESRVRAH AWNMKFNLAH DCGYSISELN EDDRRKVEEI KAELFGHGRT TDLSKGLQSP 2520
RGMGCKPEAV CSHIIIESHE KGCFRTLTSE HPQLDRHPCA FRSAGPSEMT RGRQNPSSCR 2580
AKHVNLSASL DQNNSHFKVW NSLQLKSHSP FQNFIPDEFK ISKGLRMPFD EKMDPWLSEL 2640
VEPAFVPPKE VDFHSSSQMP SPEPMKKFTT SITFSSHRHS KCISNSSVVK VGVTEGSQCT 2700
GASVGVFNSH FTEEQNPPRD LKQKTSSPSS FKMHSNSQDK EVTILAEGRR QSQKLPVDFE 2760
RSFQEEKPLE RSDFTGSHSE PSTRANCSNF KEIQISDNHT LISMGRPSST LGVNRSSSRL 2820
GVKEKNVTIT PDLPSCIFLE QRELFEQSKA PRADDHVRKH HSPSPQHQDY VAPDLPSCIF 2880
LEQRELFEQC KAPYVDHQMR ENHSPLPQGQ DSIASDLPSP ISLEQCQSKA PGVDDQMNKH 2940
HFPLPQGQDC VVEKNNQHKP KSHISNINVE AKFNTVVSQS APNHCTLAAS ASTPPSNRKA 3000
LSCVHITLCP KTSSKLDSGT LDERFHSLDA ASKARMNSEF NFDLHTVSSR SLEPTSKLLT 3060
SKPVAQDQES LGFLGPKSSL DFQVVQPSLP DSNTITQDLK TIPSQNSQIV TSRQIQVNIS 3120
DFEGHSNPEG TPVFADRLPE KMKTPLSAFS EKLSSDAVTQ ITTESPEKTL FSSEIFINAE 3180
DRGHEIIEPG NQKLRKAPVK FASSSSVQQV TFSRGTDGQP LLLPYKPSGS TKMYYVPQLR 3240
QIPPSPDSKS DTTVESSHSG SNDAIAPDFP AQVLGTRDDD LSATVNIKHK EGIYSKRVVT 3300
KASLPVGEKP LQNENADASV QVLITGDENL SDKKQQEIHS TRAVTEAAQA KEKESLQKDT 3360
ADSSAAAAAE HSAQVGDPEM KNLPDTKAIT QKEEIHRKKT VPEEAWPNNK ESLQINIEES 3420
ECHSEFENTT RSVFRSAKFY IHHPVHLPSD QDICHESLGK SVFMRHSWKD FFQHHPDKHR 3480
EHMCLPLPYQ NMDKTKTDYT RIKSLSINVN LGNKEVMDTT KSQVRDYPKH NGQISDPQRD 3540
QKVTPEQTTQ HTVSLNELWN KYRERQRQQR QPELGDRKEL SLVDRLDRLA KILQNPITHS 3600
LQVSESTHDD SRGERSVKEW SGRQQQRNKL QKKKRFKSLE KSHKNTGELK KSKVLSHHRA 3660
GRSNQIKIEQ IKFDKYILSK QPGFNYISNT SSDCRPSEES ELLTDTTTNI LSGTTSTVES 3720
DILTQTDREV ALHERSSSVS TIDTARLIQA FGHERVCLSP RRIKLYSSIT NQQRRYLEKR 3780
SKHSKKVLNT GHPLVTSEHT RRRHIQVANH VISSDSISSS ASSFLSSNST FCNKQNVHML 3840
NKGIQAGNLE IVNGAKKHTR DVGITFPTPS SSEAKLEENS DVTSWSEEKR EEKMLFTGYP 3900
EDRKLKKNKK NSHEGVSWFV PVENVESRSK KENVPNTCGP GISWFEPITK TRPWREPLRE 3960
QNCQGQHLDG RGYLAGPGRE AGRDLLRPFV RATLQESLQF HRPDFISRSG ERIKRLKLIV 4020
QERKLQSMLQ TERDALFNID RERQGHQNRM CPLPKRVFLA IQKNKPISKK EMIQRSKRIY 4080
EQLPEVQKKR EEEKRKSEYK SYRLRAQLYK KRVTNQLLGR KVPWD 4125 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS