UniProt Accession

 APT_RAT; P36972 

Genbank Protein ID

 L04970 

Genbank Nucleotide ID

 AAA40757.1 

Protein Name

 Adenine phosphoribosyltransferase 

Protein Synonyms/Alias

 APRT 

Gene Name

 Aprt 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
34	RDISPLLKDPDSFRA	acetylation	[1]
51	RLLAGHLKSTHGGKI	acetylation	[1]
114	KAELEIQKDALEPGQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 4 4 Phosphoserine (By similarity).
 MOD_RES 15 15 Phosphoserine (By similarity).
 MOD_RES 60 60 Phosphotyrosine (By similarity).
 MOD_RES 66 66 Phosphoserine (By similarity).
 MOD_RES 114 114 N6-acetyllysine (By similarity).
 MOD_RES 135 135 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Glycosyltransferase; Phosphoprotein; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 180 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0002055; F:adenine binding; IEA:Compara.
 GO:0003999; F:adenine phosphoribosyltransferase activity; IEA:EC.
 GO:0016208; F:AMP binding; IDA:RGD.
 GO:0006168; P:adenine salvage; IEA:Compara.
 GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
 GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
 GO:0007625; P:grooming behavior; IEA:Compara.
 GO:0007595; P:lactation; IDA:RGD.
 GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW. 

Interpro

 IPR005764; Ade_phspho_trans.
 IPR000836; PRibTrfase_dom. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS