UniProt Accession

 TNNT2_MOUSE; P50752; Q64360; Q64377 

Genbank Protein ID

 L47549; L47550; L47551; L47552; L47553; L47570; L47599; L47600 

Genbank Nucleotide ID

 AAA85345.1; AAA85346.1; AAA85347.1; AAA85348.1; AAA85349.1; AAA85350.1; AAA85351.1; AAA85352.1 

Protein Name

 Troponin T, cardiac muscle 

Protein Synonyms/Alias

 TnTc; Cardiac muscle troponin T; cTnT 

Gene Name

 Tnnt2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
76	EGPVEDTKPKPSRLF	ubiquitination	[1]
78	PVEDTKPKPSRLFMP	ubiquitination	[1]
91	MPNLVPPKIPDGERV	ubiquitination	[1]
189	EDEARKKKALSNMMH	ubiquitination	[1]
203	HFGGYIQKQAQTERK	ubiquitination	[1]
230	KILAERRKALAIDHL	ubiquitination	[1]
245	NEDQLREKAKELWQS	ubiquitination	[1]
266	EKFDLQEKFKQQKYE	ubiquitination	[1]
268	FDLQEKFKQQKYEIN	ubiquitination	[1]
271	QEKFKQQKYEINVLR	ubiquitination	[1]
286	NRINDNQKVSKTRGK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine; by CK2 (By similarity).
 MOD_RES 207 207 Phosphothreonine; by PKC/PRKCA.
 MOD_RES 211 211 Phosphoserine; by PKC/PRKCA.
 MOD_RES 216 216 Phosphothreonine; by PKC/PRKCA and RAF1
 MOD_RES 297 297 Phosphothreonine; by PKC/PRKCA.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0005861; C:troponin complex; IDA:MGI.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; IDA:MGI.
 GO:0005523; F:tropomyosin binding; ISS:UniProtKB.
 GO:0030172; F:troponin C binding; ISS:UniProtKB.
 GO:0031013; F:troponin I binding; ISS:UniProtKB.
 GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IMP:MGI.
 GO:0030049; P:muscle filament sliding; ISS:UniProtKB.
 GO:0032780; P:negative regulation of ATPase activity; ISS:UniProtKB.
 GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
 GO:0008016; P:regulation of heart contraction; IMP:MGI.
 GO:0051592; P:response to calcium ion; ISS:UniProtKB.
 GO:0045214; P:sarcomere organization; IMP:MGI.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:MGI. 

Interpro

 IPR001978; Troponin. 

Pfam

 PF00992; Troponin 

SMART

  

PROSITE

  

PRINTS