CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018264
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transforming growth factor-beta receptor-associated protein 1 
Protein Synonyms/Alias
 TGF-beta receptor-associated protein 1; TRAP-1; TRAP1 
Gene Name
 TGFBRAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
76LQRHLGFKKPVNELRubiquitination[1]
77QRHLGFKKPVNELRAubiquitination[1]
285QKQTLPFKEGHILQDubiquitination[1]
334EEALVLAKGARRNIPubiquitination[1]
344RRNIPKEKFQVMYRRubiquitination[1]
563VGVQVFTKRPLDEQQubiquitination[1]
571RPLDEQQKNSFNPDDubiquitination[1]
584DDIINCLKKYPKALVubiquitination[1]
601LEHLVIDKRLQKEEYubiquitination[1]
630QRASASGKGAEATETubiquitination[1, 2]
640EATETQAKLRRLLQKubiquitination[1]
647KLRRLLQKSDLYRVHubiquitination[1]
802NLIYTYDKMKLKGSSubiquitination[1]
806TYDKMKLKGSSIQLSubiquitination[1]
816SIQLSDKKLCQICQNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. 
Sequence Annotation
 DOMAIN 24 297 CNH.
 REPEAT 564 728 CHCR.  
Keyword
 Complete proteome; Cytoplasm; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 860 AA 
Protein Sequence
MMSIKAFTLV SAVERELLMG DKERVNIECV ECCGRDLYVG TNDCFVYHFL LEERPVPAGP 60
ATFTATKQLQ RHLGFKKPVN ELRAASALNR LLVLCDNSIS LVNMLNLEPV PSGARIKGAA 120
TFALNENPVS GDPFCVEVCI ISVKRRTIQM FLVYEDRVQI VKEVSTAEQP LAVAVDGHFL 180
CLALTTQYII HNYSTGVSQD LFPYCSEERP PIVKRIGRQE FLLAGPGGLG MFATVAGISQ 240
RAPVHWSENV IGAAVSFPYV IALDDEFITV HSMLDQQQKQ TLPFKEGHIL QDFEGRVIVA 300
TSKGVYILVP LPLEKQIQDL LASRRVEEAL VLAKGARRNI PKEKFQVMYR RILQQAGFIQ 360
FAQLQFLEAK ELFRSGQLDV RELISLYPFL LPTSSSFTRS HPPLHEYADL NQLTQGDQEK 420
MAKCKRFLMS YLNEVRSTEV ANGYKEDIDT ALLKLYAEAD HDSLLDLLVT ENFCLLTDSA 480
AWLEKHKKYF ALGLLYHYNN QDAAAVQLWV NIVNGDVQDS TRSDLYEYIV DFLTYCLDEE 540
LVWAYADWVL QKSEEVGVQV FTKRPLDEQQ KNSFNPDDII NCLKKYPKAL VKYLEHLVID 600
KRLQKEEYHT HLAVLYLEEV LLQRASASGK GAEATETQAK LRRLLQKSDL YRVHFLLERL 660
QGAGLPMESA ILHGKLGEHE KALHILVHEL QDFAAAEDYC LWCSEGRDPP HRQQLFHTLL 720
AIYLHAGPTA HELAVAAVDL LNRHATEFDA AQVLQMLPDT WSVQLLCPFL MGAMRDSIHA 780
RRTMQVALGL ARSENLIYTY DKMKLKGSSI QLSDKKLCQI CQNPFCEPVF VRYPNGGLVH 840
THCAASRHTN PSSSSPGTRT 860 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0046332; F:SMAD binding; IDA:UniProtKB.
 GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
 GO:0005160; F:transforming growth factor beta receptor binding; IDA:UniProtKB.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:UniProtKB.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR001180; Citron.
 IPR000547; Clathrin_H-chain/VPS_repeat.
 IPR019452; VPS39/TGF_beta_rcpt-assoc_1.
 IPR019453; VPS39/TGF_beta_rcpt-assoc_2. 
Pfam
 PF00637; Clathrin
 PF00780; CNH
 PF10366; Vps39_1
 PF10367; Vps39_2 
SMART
  
PROSITE
 PS50236; CHCR
 PS50219; CNH 
PRINTS