CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038942
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium/calcium exchanger 1 
Protein Synonyms/Alias
  
Gene Name
 Slc8a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
283EGDRPASKTEIEMDGubiquitination[1]
333ILKELKQKHPDKEIEacetylation[2]
337LKQKHPDKEIEQLIEacetylation[2]
572GNVIIPYKTIEGTARubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 934 AA 
Protein Sequence
MLRLSLPPNV SMGFRLVTLV ALLFTHVDHI TADTEAETGG NETTECTGSY YCKKGVILPI 60
WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI EVITSQEKEI TIKKPNGETT 120
KTTVRIWNET VSNLTLMALG SSAPEILLSV IEVCGHNFTA GDLGPSTIVG SAAFNMFIII 180
ALCVYVVPDG ETRKIKHLRV FFVTAAWSIF AYTWLYIILS VSSPGVVEVW EGLLTFFFFP 240
ICVVFAWVAD RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP ASKTEIEMDG KVVNSHVDNF 300
LDGALVLEVD ERDQDDEEAR REMARILKEL KQKHPDKEIE QLIELANYQV LSQQQKSRAF 360
YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNMDVVEN DPVSKVFFEQ GTYQCLENCG 420
TVALTIIRRG GDLTNTVFVD FRTEDGTANA GSDYEFTEGT VIFKPGETQK EIRVGIIDDD 480
IFEEDENFLV HLSNVRVSSE VSEDGILDSN HVSAIACLGS PNTATITIFD DDHAGIFTFE 540
EPVTHVSESI GIMEVKVLRT SGARGNVIIP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV 600
KIITIRIFDR EEYEKECSFS LVLEEPKWIR RGMKGVFPLP EEYDDKQPLT SKEEEERRIA 660
EMGRPILGEH TKLEVIIEES YEFKSTVDKL IKKTNLALVV GTNSWREQFI EAITVSAGED 720
DDDDECGEEK LPSCFDYVMH FLTVFWKVLF AFVPPTEYWN GWACFIVSIL MIGLLTAFIG 780
DLASHFGCTI GLKDSVTAVV FVALGTSVPD TFASKVAATQ DQYADASIGN VTGSNAVNVF 840
LGIGVAWSIA AIYHAANGEQ FKVSPGTLAF SVTLFTIFAF INVGVLLYRR RPEIGGELGG 900
PRTAKLLTSS LFVLLWLLYI FFSSLEAYCH IKGF 934 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0005432; F:calcium:sodium antiporter activity; IEA:Compara.
 GO:0070509; P:calcium ion import; IEA:Compara.
 GO:0055013; P:cardiac muscle cell development; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0034614; P:cellular response to reactive oxygen species; IEA:Compara.
 GO:0035050; P:embryonic heart tube development; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0003007; P:heart morphogenesis; IEA:Compara.
 GO:0048747; P:muscle fiber development; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara.
 GO:0071436; P:sodium ion export; IEA:Compara. 
Interpro
 IPR003644; Calx_beta.
 IPR001623; DnaJ_domain.
 IPR004836; Na_Ca_Ex.
 IPR002987; NaCa_exhngr1.
 IPR004837; NaCa_Exmemb. 
Pfam
 PF03160; Calx-beta
 PF01699; Na_Ca_ex 
SMART
 SM00237; Calx_beta 
PROSITE
 PS50076; DNAJ_2 
PRINTS
 PR01259; NACAEXCHNGR.
 PR01260; NACAEXCHNGR1.