UniProt Accession

 H2A2A_MOUSE; Q6GSS7; P20670; Q811M3 

Genbank Protein ID

 X16148; U62674; AY158924; AY158925; AY158953; AK002725; AK006728; BC010564; BC062255; BC089519 

Genbank Nucleotide ID

 CAA34273.1; AAB04770.1; AAO06234.1; AAO06235.1; AAO06263.1; BAB22310.1; BAB24717.1; AAH10564.3; AAH62255.1; AAH89519.1 

Protein Name

 Histone H2A type 2-A 

Protein Synonyms/Alias

 H2a-614; H2a-615; Histone H2A.2 

Gene Name

 Hist2h2aa1; Hist2h2aa2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKQGGKARA	acetylation	[1, 2]
10	GRGKQGGKARAKAKS	acetylation	[1, 2]
10	GRGKQGGKARAKAKS	methylation	[2]
75	GNAARDNKKTRIIPR	acetylation	[2]
96	RNDEELNKLLGKVTI	acetylation	[2]
96	RNDEELNKLLGKVTI	butyrylation	[2]
96	RNDEELNKLLGKVTI	crotonylation	[2]
96	RNDEELNKLLGKVTI	methylation	[2]
96	RNDEELNKLLGKVTI	ubiquitination	[3]
100	ELNKLLGKVTIAQGG	methylation	[2]
119	IQAVLLPKKTESHHK	ubiquitination	[3]
120	QAVLLPKKTESHHKA	acetylation	[2]
120	QAVLLPKKTESHHKA	methylation	[2]
126	KKTESHHKAKGK***	crotonylation	[2]
128	TESHHKAKGK*****	acetylation	[2]
130	SHHKAKGK*******	acetylation	[2]

Reference

 [1] Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain.
 Tweedie-Cullen RY, Reck JM, Mansuy IM.
 J Proteome Res. 2009 Nov;8(11):4966-82. [PMID: 19737024]
 [2] Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain.
 Tweedie-Cullen RY, Brunner AM, Grossmann J, Mohanna S, Sichau D, Nanni P, Panse C, Mansuy IM.
 PLoS One. 2012;7(5):e36980. [PMID: 22693562]
 [3] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine; by RPS6KA5.
 MOD_RES 4 4 Citrulline; alternate (By similarity).
 MOD_RES 4 4 Symmetric dimethylarginine; by PRMT5;
 MOD_RES 6 6 N6-acetyllysine.
 MOD_RES 37 37 N6-crotonyl-L-lysine.
 MOD_RES 119 119 N6-crotonyl-L-lysine.
 MOD_RES 120 120 N6-crotonyl-L-lysine; alternate (By
 MOD_RES 126 126 N6-crotonyl-L-lysine (By similarity).
 CROSSLNK 14 14 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 16 16 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 120 120 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Citrullination; Complete proteome; DNA-binding; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 130 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0006334; P:nucleosome assembly; NAS:UniProtKB. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.