| Tag | Content |
|---|
| CPLM ID | CPLM-017434 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger CCCH-type with G patch domain-containing protein |
Protein Synonyms/Alias | G patch domain-containing protein 6; Zinc finger CCCH domain-containing protein 9; Zinc finger and G patch domain-containing protein |
Gene Name | ZGPAT |
Gene Synonyms/Alias | GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZIP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 178 | YPTHKSLKPCPFFLE | ubiquitination | [1] | | 187 | CPFFLEGKCRFKENC | ubiquitination | [1] | | 343 | IGSRLLTKMGYEFGK | ubiquitination | [1] | | 372 | AVVLPRGKSLDQCVE | ubiquitination | [1] | | 421 | VFDFLNEKLQGQAPG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. |
Sequence Annotation | DOMAIN 333 379 G-patch.
ZN_FING 175 201 C3H1-type.
MOD_RES 276 276 Phosphoserine.
MOD_RES 278 278 Phosphoserine.
MOD_RES 280 280 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 531 AA |
Protein Sequence | MDEESLESAL QTYRAQLQQV ELALGAGLDS SEQADLRQLQ GDLKELIELT EASLVSVRKS 60
SLLAALDEER PGRQEDAEYQ AFREAITEAV EAPAAARGSG SETVPKAEAG PESAAGGQEE 120
EEGEDEEELS GTKVSAPYYS SWGTLEYHNA MVVGTEEAED GSAGVRVLYL YPTHKSLKPC 180
PFFLEGKCRF KENCRFSHGQ VVSLDELRPF QDPDLSSLQA GSACLAKHQD GLWHAARITD 240
VDNGYYTVKF DSLLLREAVV EGDGILPPLR TEATESDSDS DGTGDSSYAR VVGSDAVDSA 300
QSSALCPSLA VVGSDAVDSG TCSSAFAGWE VHTRGIGSRL LTKMGYEFGK GLGRHAEGRV 360
EPIHAVVLPR GKSLDQCVET LQKQTRVGKA GTNKPPRCRG RGARPGGRPA PRNVFDFLNE 420
KLQGQAPGAL EAGAAPAGRR SKDMYHASKS AKRALSLRLF QTEEKIERTQ RDIRSIQEAL 480
ARNAGRHSVA SAQLQEKLAG AQRQLGQLRA QEAGLQQEQR KADTHKKMTE F 531 |
Gene Ontology | GO:0005634; C:nucleus; IDA:UniProtKB. GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IDA:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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SMART | |
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