CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030316
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho GTPase activating protein 12 
Protein Synonyms/Alias
 Rho GTPase-activating protein 12 
Gene Name
 Arhgap12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
669GNLAVIQKLRFAVNHubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 813 AA 
Protein Sequence
MAERSGKITA GQAYIEVEYD YEYDAKDRKI VIRQGERYLL VKKTNDDWWQ VRPDENSKAF 60
YVPAQYVKEV TRKALMPPVK QATGLPNNSM KTIQSMHLQR STENVNKMPE LSSFGKPSSS 120
VQGTGLIRDA NQNFGSNYNS GQTLNLSLDL THNNGKFNSD SHSPKVSSQN RTRLFGHFPG 180
PEFLDIEKTS FSQEQSCDSA GEGSERIQQD SESGDELSSS STEQMRATTP PNQGRPDSPV 240
YANLQELKIS QSALPPLPGS PAIQVNGEWE THKDSSGRCY YYNRTTQERT WKPPRWARDV 300
STSRDFQSPG EQEPLSSEEN YHSSCFSQSD SQCGSPPRGW SEELDERGHT LYTSDYTKEK 360
WLKHVDDQGR QYYYSADGSR SEWELPKYNA SSQQQREIIK SRSLDRRLQE PIVLTKWRHS 420
TIVLDSNDKG QEKYGLLNVT KITENGKKVR KNWLSSWAVL QGSSLLFTKT QGSSTSWFGS 480
NQSKPEFTVD LKGAVIEMAS KDKSSKKNVF ELKTRQGTEL LIQSDNDAVI NDWFKVLSST 540
INNQVAEADE AAEEETPDSP GVEKHDKEKD QKELKKLRSM KGSSMDSSEQ KKTKKNLKKF 600
LTRRPTLQAV REKGYIKDQV FGSNLANLCQ RENGTVPKFV KLCIEHVEEH GLDVDGIYRV 660
SGNLAVIQKL RFAVNHDEKL DLNDSKWEDI HVITGALKMF FRELPEPLFT FNHFNDFVNA 720
IKQEPRQRVT AVKDLIRQLP KPNQDTMQIL FRHLKRVIEN GEKNRMTYQS IAIVFGPTLL 780
KPERETGNIA VHTVYQNQIV ELILLELSTV FGR 813 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR015767; Rho_GTPase_activating.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR001452; SH3_domain.
 IPR001202; WW_dom. 
Pfam
 PF00169; PH
 PF00620; RhoGAP
 PF00397; WW 
SMART
 SM00233; PH
 SM00324; RhoGAP
 SM00326; SH3
 SM00456; WW 
PROSITE
 PS50003; PH_DOMAIN
 PS50238; RHOGAP
 PS50002; SH3
 PS50020; WW_DOMAIN_2 
PRINTS