| Tag | Content |
|---|
| CPLM ID | CPLM-015654 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aryl hydrocarbon receptor repressor |
Protein Synonyms/Alias | AhR repressor; AhRR |
Gene Name | Ahrr |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 693 | SITVIPSKGSDGIFL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. |
Sequence Annotation | DOMAIN 25 78 bHLH.
DOMAIN 106 176 PAS.
REGION 555 701 Needed for transcriptional repression (By |
Keyword | Complete proteome; Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 701 AA |
Protein Sequence | MMIPSGECTY AGRKRRKPIQ KRRLTMGTEK SNPSKRHRDR LNTELDHLAS LLPFSPDIIS 60
KLDKLSVLRL SVSYLRVKSF FQALQETCVW SAPALSPEDH SSRGFPVQEG RLLLESLNGF 120
ALVVSAEGMI FYASATIVDY LGFHQTDVMH QNIYDYIHVD DRQDFCRQLH WAMDPPQVVF 180
GQSPHADTDN TVLGKLLRAQ EGGKGLPSEY SAFLTRCFIC RVRCLLDSTS GFLTMQFQGK 240
LKFLFGQKKK TPSGTALPPR LSLFCIVAPV LPSVTEMKMK SAFLKAKHRA DIVVTMDSRA 300
KAVTSLCESE LHPKLNYLAG RSNGENVISL FRGQTDRSHW TRALARSSCL CLRGGPDLLD 360
PKGTSGDREE DDQKHILRRS PGARGQREMH KYSYGLETPV HLRHLDWSTE QRSQEGTTKL 420
TRQPSKSEPS TCLVPHGSCV PYPGSQGMFS ASNMASFRES LDHPTGTYCS QMNRPLPDIH 480
QGQVDPSTCH IPQGSLGSRI PLSGMQCFTA RGFSTEDAKL PSLPVNIGTP CNPVLSLEVP 540
IKMENESGSQ DIVEASTTSC VWLGTGDMTR RHLVGFPARM HLKTEPDYRQ QVCTPHRGHG 600
ILGTNPHSRD TVGSCREHAP LYSAHCTCLS PEPPHHLFMC SHSESQHPSL DQDCRAPIVK 660
REPLDSPSWA APGHVTVPRM FPKNASITVI PSKGSDGIFL P 701 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0004871; F:signal transducer activity; IEA:InterPro. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0033235; P:positive regulation of protein sumoylation; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |