| Tag | Content |
|---|
| CPLM ID | CPLM-019230 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interleukin-17 receptor A |
Protein Synonyms/Alias | IL-17 receptor A; IL-17RA; CDw217; CD217 |
Gene Name | IL17RA |
Gene Synonyms/Alias | IL17R |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 134 | VRFEFLSKLRHHHRR | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. |
Sequence Annotation | DOMAIN 377 534 SEFIR.
CARBOHYD 49 49 N-linked (GlcNAc...).
CARBOHYD 54 54 N-linked (GlcNAc...).
CARBOHYD 67 67 N-linked (GlcNAc...).
CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
CARBOHYD 225 225 N-linked (GlcNAc...).
CARBOHYD 242 242 N-linked (GlcNAc...) (Potential).
CARBOHYD 265 265 N-linked (GlcNAc...).
DISULFID 43 50
DISULFID 57 126
DISULFID 185 196
DISULFID 245 276
DISULFID 290 294 |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 866 AA |
Protein Sequence | MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC TVKNSTCLDD 60
SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL QTDASILYLE GAELSVLQLN 120
TNERLCVRFE FLSKLRHHHR RWRFTFSHFV VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF 180
LVPDCEHARM KVTTPCMSSG SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM 240
ENHSCFEHMH HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT 300
VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP GSEKYSDDTK 360
YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ FLLTACGTEV ALDLLEEQAI 420
SEAGVMTWVG RQKQEMVESN SKIIVLCSRG TRAKWQALLG RGAPVRLRCD HGKPVGDLFT 480
AAMNMILPDF KRPACFGTYV VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE 540
MFQPGRMHRV GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS 600
LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL EPHLQPRGQP 660
APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG EACPLLGSPG AGRNSVLFLP 720
VDPEDSPLGS STPMASPDLL PEDVREHLEG LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT 780
PYEEEQRQSV QSDQGYISRS SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ 840
RQLLFRQLQK NSGWDTMGSE SEGPSA 866 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB. GO:0030368; F:interleukin-17 receptor activity; NAS:UniProtKB. GO:0072537; P:fibroblast activation; IDA:BHF-UCL. GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Compara. GO:0032747; P:positive regulation of interleukin-23 production; IDA:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |