UniProt Accession

 ACOT2_RAT; O55171; O88268 

Genbank Protein ID

 Y09333; AB010429 

Genbank Nucleotide ID

 CAA70513.1; BAA32539.1 

Protein Name

 Acyl-coenzyme A thioesterase 2, mitochondrial 

Protein Synonyms/Alias

 Acyl-CoA thioesterase 2; ARTISt/p43; Acyl coenzyme A thioester hydrolase; MTE-I; Very-long-chain acyl-CoA thioesterase 

Gene Name

 Acot2 

Gene Synonyms/Alias

 Mte1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
141	LVKRDVQKPYVVELE	acetylation	[1]
344	LQSPLVDKKSFIPVE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Most active on substrates with chain lengths ranging from C14-C20. 

Sequence Annotation

 ACT_SITE 273 273 Charge relay system (By similarity).
 ACT_SITE 365 365 Charge relay system (By similarity).
 ACT_SITE 399 399 Charge relay system (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Hydrolase; Mitochondrion; Reference proteome; Serine esterase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 453 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0016290; F:palmitoyl-CoA hydrolase activity; IDA:RGD.
 GO:0006637; P:acyl-CoA metabolic process; IDA:RGD.
 GO:0033555; P:multicellular organismal response to stress; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0070849; P:response to epidermal growth factor stimulus; IEP:RGD.
 GO:0009725; P:response to hormone stimulus; IEP:RGD.
 GO:0001666; P:response to hypoxia; IDA:HGNC.
 GO:0031667; P:response to nutrient levels; IEP:RGD.
 GO:0042760; P:very long-chain fatty acid catabolic process; IDA:RGD. 

Interpro

 IPR016662; Acyl-CoA_thioEstase_long-chain.
 IPR014940; BAAT_C.
 IPR006862; Thio_Ohase/aa_AcTrfase. 

Pfam

 PF08840; BAAT_C
 PF04775; Bile_Hydr_Trans 

SMART

  

PROSITE

  

PRINTS