UniProt Accession

 ROA2_MOUSE; O88569; B9EJ02; Q3UVJ5; Q6PCV9; Q8C2A0; Q8CJ71; Q91ZR9; Q9R204 

Genbank Protein ID

 AF406651; AF452567; AF073990; AF073993; AK089012; AK137214; BC059107; BC141253 

Genbank Nucleotide ID

 AAK98601.2; AAN16352.1; AAD29846.1; AAC26867.1; BAC40700.1; BAE23274.1; AAH59107.1; AAI41254.1 

Protein Name

 Heterogeneous nuclear ribonucleoproteins A2/B1 

Protein Synonyms/Alias

 hnRNP A2/B1 

Gene Name

 Hnrnpa2b1 

Gene Synonyms/Alias

 Hnrpa2b1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	REKEQFRKLFIGGLS	ubiquitination	[1]
46	NYYEQWGKLTDCVVM	acetylation	[2]
46	NYYEQWGKLTDCVVM	ubiquitination	[1]
59	VMRDPASKRSRGFGF	ubiquitination	[1]
104	VAREESGKPGAHVTV	acetylation	[3]
104	VAREESGKPGAHVTV	ubiquitination	[1]
112	PGAHVTVKKLFVGGI	acetylation	[2]
112	PGAHVTVKKLFVGGI	ubiquitination	[1]
113	GAHVTVKKLFVGGIK	acetylation	[2]
113	GAHVTVKKLFVGGIK	ubiquitination	[1]
120	KLFVGGIKEDTEEHH	acetylation	[2, 3, 4]
120	KLFVGGIKEDTEEHH	succinylation	[3]
120	KLFVGGIKEDTEEHH	ubiquitination	[1]
152	TDRQSGKKRGFGFVT	ubiquitination	[1]
168	DDHDPVDKIVLQKYH	acetylation	[2, 3]
168	DDHDPVDKIVLQKYH	ubiquitination	[1]
173	VDKIVLQKYHTINGH	acetylation	[2]
173	VDKIVLQKYHTINGH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus (By similarity). 

Sequence Annotation

 DOMAIN 21 104 RRM 1.
 DOMAIN 112 191 RRM 2.
 REGION 308 347 Nuclear targeting sequence (By
 MOTIF 9 15 Nuclear localization signal (Potential).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 104 104 N6,N6-dimethyllysine (By similarity).
 MOD_RES 149 149 Phosphoserine (By similarity).
 MOD_RES 168 168 N6-acetyllysine (By similarity).
 MOD_RES 173 173 N6-acetyllysine (By similarity).
 MOD_RES 203 203 Dimethylated arginine; alternate (By
 MOD_RES 203 203 Omega-N-methylarginine; alternate (By
 MOD_RES 212 212 Phosphoserine (By similarity).
 MOD_RES 213 213 Dimethylated arginine; alternate (By
 MOD_RES 213 213 Omega-N-methylarginine; alternate (By
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 231 231 Phosphoserine (By similarity).
 MOD_RES 236 236 Phosphoserine (By similarity).
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 324 324 Phosphoserine.
 MOD_RES 331 331 Phosphotyrosine (By similarity).
 MOD_RES 341 341 Phosphoserine (By similarity).
 MOD_RES 344 344 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 353 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; ISS:HGNC.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0097157; F:pre-mRNA intronic binding; IDA:MGI.
 GO:0043047; F:single-stranded telomeric DNA binding; ISS:HGNC.
 GO:0006397; P:mRNA processing; ISS:HGNC.
 GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IMP:MGI.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0050658; P:RNA transport; ISS:HGNC. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS