CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015699
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Xaa-Pro dipeptidase 
Protein Synonyms/Alias
 X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase 
Gene Name
 pepQ 
Gene Synonyms/Alias
 STM3984 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
77LLVDGVNKPKLWFYLacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Splits dipeptides with a prolyl residue in the C- terminal position (By similarity). 
Sequence Annotation
 METAL 246 246 Manganese 2 (By similarity).
 METAL 257 257 Manganese 1 (By similarity).
 METAL 257 257 Manganese 2 (By similarity).
 METAL 339 339 Manganese 1 (By similarity).
 METAL 384 384 Manganese 1 (By similarity).
 METAL 423 423 Manganese 1 (By similarity).
 METAL 423 423 Manganese 2 (By similarity).  
Keyword
 Complete proteome; Dipeptidase; Hydrolase; Manganese; Metal-binding; Metalloprotease; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 443 AA 
Protein Sequence
MESLAALYKN HIVTLQERTR DVLARFKLDA LLIHSGELFN VFLDDHPYPF KVNPQFKAWV 60
PVTQVPNCWL LVDGVNKPKL WFYLPVDYWH NVEPLPTSFW TEEVEVVALP KADGIGSQLP 120
AARGNIGYIG PVPERALQLD IAASNINPKG VIDYLHYYRA YKTDYELACM REAQKMAVSG 180
HRAAEEAFRS GMSEFDINLA YLTATGHRDT DVPYSNIVAL NEHAAVLHYT KLDHQAPSEM 240
RSFLLDAGAE YNGYAADLTR TWSAKSDNDY AHLVKDVNDE QLALIATMKA GVSYVDYHIQ 300
FHQRIAKLLR KHQIITDMSE EAMVENDLTG PFMPHGIGHP LGLQVHDVAG FMQDDSGTHL 360
AAPSKYPYLR CTRVLQPRMV LTIEPGIYFI ESLLAPWREG PFSKHFNWQK IEALKPFGGI 420
RIEDNVVIHE NGVENMTRDL KLA 443 
Gene Ontology
 GO:0016805; F:dipeptidase activity; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008235; F:metalloexopeptidase activity; IEA:HAMAP.
 GO:0016795; F:phosphoric triester hydrolase activity; IEA:InterPro.
 GO:0009987; P:cellular process; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR000994; Pept_M24_structural-domain.
 IPR001131; Peptidase_M24B_aminopep-P_CS.
 IPR022846; X_Pro_dipept. 
Pfam
 PF00557; Peptidase_M24 
SMART
  
PROSITE
 PS00491; PROLINE_PEPTIDASE 
PRINTS