CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024500
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Putative zinc finger protein LOC730110 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60ITCLEQGKEPWNVKRubiquitination[1]
66GKEPWNVKRHEMVAEubiquitination[1, 2]
283KRIHTGEKPYKCEECubiquitination[1]
286HTGEKPYKCEECGKAubiquitination[1, 2]
314HAGEKPYKCEECGKSubiquitination[1]
425KIIHTGEKPYKCEECubiquitination[1]
428HTGEKPYKCEECGKAubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be involved in transcriptional regulation (By similarity). 
Sequence Annotation
 DOMAIN 4 75 KRAB.
 ZN_FING 173 195 C2H2-type 1.
 ZN_FING 201 223 C2H2-type 2.
 ZN_FING 229 251 C2H2-type 3; degenerate.
 ZN_FING 257 279 C2H2-type 4.
 ZN_FING 285 307 C2H2-type 5.
 ZN_FING 313 337 C2H2-type 6; degenerate.
 ZN_FING 343 365 C2H2-type 7.
 ZN_FING 371 393 C2H2-type 8.
 ZN_FING 399 421 C2H2-type 9.
 ZN_FING 427 449 C2H2-type 10.
 ZN_FING 455 477 C2H2-type 11.
 ZN_FING 483 505 C2H2-type 12.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MGVLTFRDVA IEFSLEEWHC LDTAQQNLYR NVMLENYRNL VFLGIAASKP DLITCLEQGK 60
EPWNVKRHEM VAEPPVVCSY FAQDLWPNQG IKNCFQKVIL RRYKKCGHEN LQLGKYRKSM 120
DECKVHEECC NGFNQCSRTT QSKILQCDKY VKVFHKFSNS NRYKIRHTGK KPFKCKECEK 180
SFFMLSHSAQ HKRIHSGEKP YKCKECGKAY NEASNLSTHK RIHTGKKPYK CEDCGKAFNW 240
LSHLTTQKII HTGKKPYKCE DCGKAFNQSA NLTTHKRIHT GEKPYKCEEC GKAFSQSSTL 300
TTHKIIHAGE KPYKCEECGK SFNQSSVLHL TTRKRIHSGE KPYKCEECGK AFKQSSTLTT 360
HKRIHSGEKF YKCEVCSKAF SRFSHLTTHK RIHTGEKPYK CEECGKAFNL SSHLTTHKII 420
HTGEKPYKCE ECGKAFNQSS TLSKHKVIHT GEKPYKCGEC GKAFNQSSHL TTHKIIHTGE 480
KPYKCEECGK AFNNSSILNR HKMIHTGEKL YKLESCNNAC DNISNISKHK VIHTGENFYK 540
CEQCGKT 547 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS