UniProt Accession

 PP1B_RAT; P62142; P37140 

Genbank Protein ID

 D90164; BC062033 

Genbank Nucleotide ID

 BAA14195.1; AAH62033.1 

Protein Name

 Serine/threonine-protein phosphatase PP1-beta catalytic subunit 

Protein Synonyms/Alias

 PP-1B 

Gene Name

 Ppp1cb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
25	VRGCRPGKIVQMTEA	acetylation	[1]
146	CKRRFNIKLWKTFTD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). 

Sequence Annotation

 ACT_SITE 124 124 Proton donor (By similarity).
 METAL 63 63 Iron (By similarity).
 METAL 65 65 Iron (By similarity).
 METAL 91 91 Iron (By similarity).
 METAL 91 91 Manganese (By similarity).
 METAL 123 123 Manganese (By similarity).
 METAL 172 172 Manganese (By similarity).
 METAL 247 247 Manganese (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 316 316 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Carbohydrate metabolism; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; Glycogen metabolism; Hydrolase; Iron; Manganese; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0042587; C:glycogen granule; IDA:RGD.
 GO:0070688; C:MLL5-L complex; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0000164; C:protein phosphatase type 1 complex; IDA:RGD.
 GO:0072357; C:PTW/PP1 phosphatase complex; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0017018; F:myosin phosphatase activity; ISS:UniProtKB.
 GO:0050115; F:myosin-light-chain-phosphatase activity; ISS:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
 GO:0006470; P:protein dephosphorylation; IDA:RGD.
 GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.
 GO:0005979; P:regulation of glycogen biosynthetic process; IDA:RGD.
 GO:0005981; P:regulation of glycogen catabolic process; IDA:RGD. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.