CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase HUWE1 
Protein Synonyms/Alias
  
Gene Name
 Huwe1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1904LVKTTPLKPSSLPVIacetylation[1]
2222NTVNAALKPLETLSRacetylation[1]
4113YFTRSFYKHILGKSVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4181 AA 
Protein Sequence
MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120
TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA 180
ECCRDLQMLK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM 240
ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI 300
LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP 360
VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG 420
DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ 480
RPSTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL 540
KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV 600
LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG 660
SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT TSAPPPRSNH 720
AAEEASSEDE EEEEVQAMQS FNSAQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI 780
LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV 840
LQEGLLQLDL ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH 900
AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL 960
PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS MDASAQGLLE GIELDGDTLA 1020
PMETDEPSSS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR 1080
QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP 1140
MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD 1200
AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF TCIKNLWNRK 1260
PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEEAGQEEGG SRREPQVNQQ 1320
QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPII GGVVRDLSMS EEDQMMRAIA 1380
MSLGQDIPMD QRAESPEVTK AFKRKVREVN THSSQPFGLP LSSFSVDDPN EALGFHSLVS 1440
LLNEEFILLL LLTTTTTTTT TTTTTTTTTT TTIITIMVKA LVNQYVLRLL RKKLQLIVLH 1500
NISVSSSNIL YNLKQKEEYG VKIRKLTGFF GLKIPRNKKI DIEKPLSVLN VQCIFFCISF 1560
KQLSTDSLVI LTIEDTLCIC ILFYLQSNSN NWRWFDDRSG RWCSYSASNN STIDSAWKSG 1620
ETSVRFTAGR RRYTVQFTTM VQVNEETGNR RPVMLTLLRV PRLSKNSKSS NGQELEKTLE 1680
ESKETDIKRK ENKGNDIPLA LESTNTEKDA SLEETKIGEI LIQGLTEDMV TVLIRACVSM 1740
LGVPVGPTTL HTLRPRLRAP RGHNYMMFAE PESTRILSLT QSGFPMGFTP LRCTLLLRAH 1800
SLRPCTLRHT MEKVSIFSAT SGAGSTTSGV VSGSLGSREI NYILRVLGPA ACRNPDIFTE 1860
VANCCIRIAL PAPRGSGTAS DDEFENLRIK GPNAVQLVKT TPLKPSSLPV IPDTIKEVIY 1920
DMLNALAAYH APEEADKSDP KPGGMTQEVG QLLQDMGDDV YQQYRSLTRQ SSDFDTQSGF 1980
SLNSQVFAAD GAPAETSTTG TSQGEGASTP EETREGKKDK EGDRTSEEGK QKGKGSKPLM 2040
PTSTILRLLA ELVRSYVGIA TLIANYSYTV GQSELIKEDC SVLAFVLDHL LPHTQNAEDK 2100
DTPALARLFL ASLAAAGSGT DAQVALVNEV KAALGRALAM AESTEKHARL QAVMCIISTI 2160
MESCPSTSSF YSSATAKTQH NGMNNIIRLF LKKGLVNDLA RVPHSLDLSS PNMANTVNAA 2220
LKPLETLSRI VNQPSSLFGS KSASSKSKSE QDAQGASQDS SSHQQDPGEP GEAEVQEEDH 2280
DVTQTEVADG DIMDGEAETD SVVIAGQPEV LSSQEMQVEN ELEDLIDELL ERDGGSGNST 2340
IIVSRSGEDE SQEDVLMDEA PSNLSQASTL QANREDSMNI LDPEDEEEHT QEEDSSGSNE 2400
DEDDSQDEEE EEEEDEEDDQ EDDEGEEGDE DDDDDGSEME LDEDYPDMNA SPLVRFERFD 2460
REDDLIIEFD NMFSSATDIP PSPGNIPTTH PLMVRHADHS SLTLGSGSST TRLTQGIGRS 2520
QRTLRQLTAN TGHTIHVHYP GNRQPNPPLI LQRLLGPSAA ADILQLSSSL PLQSRGRARL 2580
LVGNDDVHII ARSDDELLDD FFHDQSTATS QAGKFMHIPT ALTRWTEECK VLDAESMHDC 2640
VSVVISHLIS HSYFLLASLS PERAEDSDAL TAVSSQLEDV QGRPDKWNRD QSAQCTVSKT 2700
NDSTEQNVSD GTPMPDSYPT TPSSTDAPTS ESKETLGTLQ PSQQQPTLPP PPSLGEISQE 2760
LQSPAEEVGN STQLLMPIEL EELGPTRPSG EAETTQMELS PAPTITSLSP ERAEDSDALT 2820
AVSSQLEGSP MDTSSLASCT LEEAVGDTPA AGSSEQPTAG SSTPGDAPSV GADVQGRPDV 2880
SRESTQPPED SSPPASSESS STRDSAVAIS GADSRGILEE PLPSTSSEEE DPLAGISLPE 2940
GVDPSFLAAL PDDIRREVLQ NQLGIRPPTR TAPSTNSSTP AVVGNPGVTE VSPEFLAALP 3000
PAIQEEVCEQ EYDEQQRREL AQNASSDTPM DPVTFIQTLP SDLRRSVLED MEDSVLAVMP 3060
PDIAAEAQAL RREQEARQRQ LMHERLFGHS STSALSAILR SPAFTSRLSG NRGVQYTRLA 3120
VQRGGTFQMG GSSSHNRPSG SNVDTLLRLR GRLLLDHEAL SCLLVLLFVD EPKLNTSRLH 3180
RVLRNLCYHA QTRHWVIRSL LSILQRSSES ELCIETPKLS TSEERGKKSS KSCASSSHEN 3240
RPLDLLHKME SKSSNQLSWL SVSMDAALGC RTNIFQIQRS GGRKHTEKHA SSGSTVHIHP 3300
QAAPVVCRHV LDTLIQLAKF YLFIKTTVCT AATAISTITV AASTTVTTPT TATTTVSSKC 3360
YKSKLWGLCH GSHLAPTSYP DRQDLGTEPR ALCLLGKYST TELNPQPRMF ILNPSPHTTT 3420
VCVYGVCMYT RLYKAKPLAP PKGEVEKISQ VGDELRIVCK GWRDGSVVKS TDCPSRGPEF 3480
KSQRLHGASQ PSVMGSDALF WPIQCSTSRL MPSPSFNMFC FLEASTTKGN KSPAKVGEGG 3540
SSSVDFKMVS SGLTENQLQL SVEVLTSHSC SEEGLEDAAN VLLQLSRGDS GTRDTVLKLL 3600
LNGARHLGYT LCKQIGTLLA ELREYNLEQQ RRAQCETLSP DGLPEEQPQT TKLKGKMQSR 3660
FDMAENVVIV ASQKRPLGGR ELQLPSMSML TSKTSTQKFF LRVLQVIIQL RDDTRRANKK 3720
AKQTGRLGSS GLGSASSIQA AVRQLEAEAD AIIQMVREGQ RARRQQQAAT SESSNQSETS 3780
VRREESPMDV DQPSPSAQDT QSIVVSDGTP QGEKEKEERP PELPLLSEQL SLDELWDMLG 3840
ECLKELEESH DQHAVLVLQP AVEAFFLVHA TERESKPPVR DTRESQLAHI KDEPPPLSPA 3900
PLTPATPSSL DPFFSREPSS MHISSSLPPD TQKFLRFAET HRTVLNQILR QSTTHLADGP 3960
FAVLVDYIRV LDFDVKRKYF RQELERLDEG LRKEDMAVHV RRDHVFEDSY RELHRKSPEE 4020
MKNRLYIVFE GEEGQDAGGL LREWYMIISR EMFNPMYALF RTSPGDRVTY TINPSSHCNP 4080
NHLSYFKFVG RIVAKAVYDN RLLECYFTRS FYKHILGKSV RYTDMESEDY HFYQGLVYLL 4140
ENDVSTLGYD LTFSTEVQEF GVCEVRDLKP NGANILVTEE N 4181 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:GOC. 
Interpro
 IPR016024; ARM-type_fold.
 IPR025527; DUF4414.
 IPR010309; E3_Ub_ligase_DUF908.
 IPR010314; E3_Ub_ligase_DUF913.
 IPR000569; HECT.
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk.
 IPR004170; WWE-dom. 
Pfam
 PF14377; DUF4414
 PF06012; DUF908
 PF06025; DUF913
 PF00632; HECT
 PF00627; UBA
 PF02825; WWE 
SMART
 SM00119; HECTc
 SM00165; UBA 
PROSITE
 PS50237; HECT
 PS50030; UBA
 PS50918; WWE 
PRINTS