| Tag | Content |
|---|
| CPLM ID | CPLM-022631 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chromobox protein homolog 8 |
Protein Synonyms/Alias | Polycomb 3 homolog; Pc3; mPc3 |
Gene Name | Cbx8 |
Gene Synonyms/Alias | Pc3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 213 | ETSSGTGKFPAGHSV | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). |
Sequence Annotation | DOMAIN 11 69 Chromo.
MOD_RES 110 110 Phosphoserine (By similarity).
MOD_RES 164 164 Phosphoserine (By similarity).
MOD_RES 229 229 Phosphoserine.
MOD_RES 238 238 Phosphoserine (By similarity).
MOD_RES 325 325 Phosphoserine (By similarity). |
Keyword | 3D-structure; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 362 AA |
Protein Sequence | MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD ARLLAAFEER 60
EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSTR GIRIPYPGRS PQDLASTSRA 120
REGLRNTGLP PPGSSTSTCR ADPPRDRDRE RDRGTSRVDD KPSSPGDSSK KRGPKPRKEP 180
LDPSQRPLGE PSAGLGEYLK GRKLDETSSG TGKFPAGHSV IQLARRQDSD LVQYGVTSPS 240
SAEASSKLAV DTFPARVIKH RAAFLEAKGQ GALDPGGARV RHSSGTPASV GSLYRDMGAQ 300
GGRPSLIARI PVARILGDPE EESWSPSLTN LEKVVVTDVT SNFLTVTIKE SNTDQGFFKE 360
KR 362 |
Gene Ontology | GO:0000792; C:heterochromatin; IDA:UniProtKB. GO:0000790; C:nuclear chromatin; IEA:Compara. GO:0035102; C:PRC1 complex; ISS:UniProtKB. GO:0000151; C:ubiquitin ligase complex; IDA:MGI. GO:0003727; F:single-stranded RNA binding; IDA:UniProtKB. GO:0006342; P:chromatin silencing; ISS:MGI. GO:0016574; P:histone ubiquitination; IDA:MGI. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |