| Tag | Content |
|---|
| CPLM ID | CPLM-021347 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Semaphorin-4A |
Protein Synonyms/Alias | Semaphorin-B; Sema B |
Gene Name | SEMA4A |
Gene Synonyms/Alias | SEMAB; SEMB; UNQ783/PRO1317 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 219 | LGSQPVLKTDNFLRW | ubiquitination | [1] | | 535 | APNLNSWKQDMERGN | ubiquitination | [1] | | 662 | GIPREHVKVPLTRVS | ubiquitination | [1] | | 727 | ETLRPGEKAPLSREQ | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). |
Sequence Annotation | DOMAIN 36 494 Sema.
DOMAIN 496 548 PSI.
DOMAIN 573 631 Ig-like C2-type.
MOD_RES 744 744 Phosphothreonine (By similarity).
MOD_RES 747 747 Phosphoserine (By similarity).
CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
CARBOHYD 496 496 N-linked (GlcNAc...) (Potential).
CARBOHYD 607 607 N-linked (GlcNAc...) (Potential).
DISULFID 113 124 By similarity.
DISULFID 142 151 By similarity.
DISULFID 269 379 By similarity.
DISULFID 293 339 By similarity.
DISULFID 497 514 By similarity.
DISULFID 506 523 By similarity.
DISULFID 580 624 By similarity. |
Keyword | Adaptive immunity; Alternative splicing; Angiogenesis; Cell membrane; Complete proteome; Cone-rod dystrophy; Developmental protein; Differentiation; Disease mutation; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; Retinitis pigmentosa; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 761 AA |
Protein Sequence | MALPALGLDP WSLLGLFLFQ LLQLLLPTTT AGGGGQGPMP RVRYYAGDER RALSFFHQKG 60
LQDFDTLLLS GDGNTLYVGA REAILALDIQ DPGVPRLKNM IPWPASDRKK SECAFKKKSN 120
ETQCFNFIRV LVSYNVTHLY TCGTFAFSPA CTFIELQDSY LLPISEDKVM EGKGQSPFDP 180
AHKHTAVLVD GMLYSGTMNN FLGSEPILMR TLGSQPVLKT DNFLRWLHHD ASFVAAIPST 240
QVVYFFFEET ASEFDFFERL HTSRVARVCK NDVGGEKLLQ KKWTTFLKAQ LLCTQPGQLP 300
FNVIRHAVLL PADSPTAPHI YAVFTSQWQV GGTRSSAVCA FSLLDIERVF KGKYKELNKE 360
TSRWTTYRGP ETNPRPGSCS VGPSSDKALT FMKDHFLMDE QVVGTPLLVK SGVEYTRLAV 420
ETAQGLDGHS HLVMYLGTTT GSLHKAVVSG DSSAHLVEEI QLFPDPEPVR NLQLAPTQGA 480
VFVGFSGGVW RVPRANCSVY ESCVDCVLAR DPHCAWDPES RTCCLLSAPN LNSWKQDMER 540
GNPEWACASG PMSRSLRPQS RPQIIKEVLA VPNSILELPC PHLSALASYY WSHGPAAVPE 600
ASSTVYNGSL LLIVQDGVGG LYQCWATENG FSYPVISYWV DSQDQTLALD PELAGIPREH 660
VKVPLTRVSG GAALAAQQSY WPHFVTVTVL FALVLSGALI ILVASPLRAL RARGKVQGCE 720
TLRPGEKAPL SREQHLQSPK ECRTSASDVD ADNNCLGTEV A 761 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0004872; F:receptor activity; IEA:InterPro. GO:0001525; P:angiogenesis; IEA:UniProtKB-KW. GO:0007411; P:axon guidance; TAS:Reactome. GO:0016525; P:negative regulation of angiogenesis; IEA:Compara. GO:0008360; P:regulation of cell shape; IEA:Compara. GO:0010594; P:regulation of endothelial cell migration; IEA:Compara. GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Compara. GO:0045063; P:T-helper 1 cell differentiation; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |