CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019288
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tectonic-2 
Protein Synonyms/Alias
  
Gene Name
 TCTN2 
Gene Synonyms/Alias
 C12orf38; TECT2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
411AEINAHQKGIMTQRFubiquitination[1]
443NPGYQLGKPVRALNIubiquitination[1, 2]
621SASVQFIKIPAQLPHubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity). 
Sequence Annotation
 CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).
 CARBOHYD 156 156 N-linked (GlcNAc...) (Potential).
 CARBOHYD 391 391 N-linked (GlcNAc...) (Potential).
 CARBOHYD 497 497 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell projection; Ciliopathy; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Glycoprotein; Joubert syndrome; Meckel syndrome; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 697 AA 
Protein Sequence
MGFQPPAALL LRLFLLQGIL RLLWGDLAFI PPFIRMSGPA VSASLVGDTE GVTVSLAVLQ 60
DEAGILPIPT CGVLNNETED WSVTVIPGAK VLEVTVRWKR GLDWCSSNET DSFSESPCIL 120
QTLLVSASHN SSCSAHLLIQ VEIYANSSLT HNASENVTVI PNQVYQPLGP CPCNLTAGAC 180
DVRCCCDQEC SSNLTTLFRR SCFTGVFGGD VNPPFDQLCS AGTTTRGVPD WFPFLCVQSP 240
LANTPFLGYF YHGAVSPKQD SSFEVYVDTD AKDFADFGYK QGDPIMTVKK AYFTIPQVSL 300
AGQCMQNAPV AFLHNFDVKC VTNLELYQER DGIINAKIKN VALGGIVTPK VIYEEATDLD 360
KFITNTETPL NNGSTPRIVN VEEHYIFKWN NNTISEINVK IFRAEINAHQ KGIMTQRFVV 420
KFLSYNSGNE EELSGNPGYQ LGKPVRALNI NRMNNVTTLH LWQSAGRGLC TSATFKPILF 480
GENVLSGCLL EVGINENCTQ LRENAVERLD SLIQATHVAM RGNSDYADLS DGWLEIIRVD 540
APDPGADPLA SSVNGMCLDI PAHLSIRILI SDAGAVEGIT QQEILGVETR FSSVNWQYQC 600
GLTCEHKADL LPISASVQFI KIPAQLPHPL TRFQINYTEY DCNRNEVCWP QLLYPWTQYY 660
QGELHSQCVA KGLLLLLFLT LALFLSNPWT RICKAYS 697 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell.
 GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB. 
Interpro
 IPR011677; DUF1619. 
Pfam
 PF07773; DUF1619 
SMART
  
PROSITE
  
PRINTS