CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038260
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calsequestrin 
Protein Synonyms/Alias
  
Gene Name
 Casq2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
40RVVSLSEKNLKQMLKubiquitination[1]
64HEPVSSDKVSQKQFQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 312 AA 
Protein Sequence
MKRIYLLMVG VYLLSLSGAE EGLNFPTYDG KDRVVSLSEK NLKQMLKRYD LLCLYYHEPV 60
SSDKVSQKQF QLKEIVLELV AQVLEHKNIG FVMVDSRKEA KLAKRLDYKA FQEAAEHFQP 120
YIKFFATFDK AVAKKLSLKM NEVGFYEPFM DEPNVIPNKP YTEEELVEFV KEHQRPTLRR 180
LRPEDMFETW EDDLNGIHIV AFAEKSDPDG YEFLEILKQV ARDNTDNPDL SILWIDPDDF 240
PLLVAYWEKT FKIDLFKPQI GVVNVTDADS IWMEIPDDDD LPTAEELEDW IEDVLSGKIN 300
TEDDDNEDED DD 312 
Gene Ontology
 GO:0016529; C:sarcoplasmic reticulum; TAS:MGI.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IDA:MGI. 
Interpro
 IPR001393; Calsequestrin.
 IPR018233; Calsequestrin_CS.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF01216; Calsequestrin 
SMART
  
PROSITE
 PS00863; CALSEQUESTRIN_1
 PS00864; CALSEQUESTRIN_2 
PRINTS
 PR00312; CALSEQUESTRN.