UniProt Accession

 GPX3_RAT; P23764; Q6P6H2 

Genbank Protein ID

 D00680; BC062227 

Genbank Nucleotide ID

 BAA00587.2; AAH62227.1 

Protein Name

 Glutathione peroxidase 3 

Protein Synonyms/Alias

 GPx-3; GSHPx-3; Plasma glutathione peroxidase; GPx-P; GSHPx-P 

Gene Name

 Gpx3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
147	VNGEKEQKFYTFLKN	acetylation	[1]
175	RLFWEPMKIHDIRWN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. 

Sequence Annotation

 ACT_SITE 73 73  

Keyword

 Complete proteome; Oxidoreductase; Peroxidase; Reference proteome; Secreted; Selenocysteine; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0043295; F:glutathione binding; IDA:RGD.
 GO:0004602; F:glutathione peroxidase activity; ISS:UniProtKB.
 GO:0008430; F:selenium binding; ISS:UniProtKB.
 GO:0007565; P:female pregnancy; IEP:RGD.
 GO:0006749; P:glutathione metabolic process; IDA:RGD.
 GO:0042744; P:hydrogen peroxide catabolic process; IDA:RGD.
 GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
 GO:0051412; P:response to corticosterone stimulus; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0002238; P:response to molecule of fungal origin; IEP:RGD.
 GO:0010269; P:response to selenium ion; IEP:RGD. 

Interpro

 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS

 PR01011; GLUTPROXDASE.