UniProt Accession

 PEA15_MOUSE; Q62048; Q3U5N7 

Genbank Protein ID

 X86694; AK089070; AK153141; AK153493; AK161635; AK161977; BC038282 

Genbank Nucleotide ID

 CAA60387.1; BAC40734.1; BAE31752.1; BAE32041.1; BAE36504.1; BAE36662.1; AAH38282.1 

Protein Name

 Astrocytic phosphoprotein PEA-15 

Protein Synonyms/Alias

 15 kDa phosphoprotein enriched in astrocytes 

Gene Name

 Pea15 

Gene Synonyms/Alias

 Pea15a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
54	SFLESHNKLDKDNLS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). 

Sequence Annotation

 DOMAIN 3 81 DED.
 REGION 98 107 Microtubule-binding (Potential).
 REGION 122 129 Microtubule-binding (Potential).
 MOD_RES 61 61 Phosphoserine.
 MOD_RES 104 104 Phosphoserine; by PKC.
 MOD_RES 116 116 Phosphoserine; by CaMK2.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Sugar transport; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 130 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005875; C:microtubule associated complex; NAS:UniProtKB.
 GO:0005080; F:protein kinase C binding; TAS:MGI.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; TAS:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
 GO:0046325; P:negative regulation of glucose import; ISS:UniProtKB.
 GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
 GO:0043278; P:response to morphine; IEA:Compara. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR001875; DED. 

Pfam

 PF01335; DED 

SMART

 SM00031; DED 

PROSITE

 PS50168; DED 

PRINTS