UniProt Accession

 MSRA_HUMAN; Q9UJ68; E9PAS8; Q52TC4; Q549N4; Q66MI7 

Genbank Protein ID

 AJ242973; AY690665; AY958429; AY958430; AY958431; AY958432; AY958432; AY958432; AK293488; AF086925; AF183420; AC023385; AC034111; AC079200; AC112673; CH471157; CH471157; BC054033 

Genbank Nucleotide ID

 CAB59628.1; AAU11088.1; AAY17426.1; AAY17427.1; AAY17428.1; AAY17429.1; AAY17430.1; AAY17431.1; BAH11521.1; AAP97154.1; AAG09689.1; EAW65584.1; EAW65585.1; AAH54033.1 

Protein Name

 Mitochondrial peptide methionine sulfoxide reductase 

Protein Synonyms/Alias

 Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Protein-methionine-S-oxide reductase; PMSR 

Gene Name

 MSRA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
112	YKEVCSEKTGHAEVV	ubiquitination	[1]
167	AIYPTSAKQMEAALS	ubiquitination	[1]
176	MEAALSSKENYQKVL	ubiquitination	[1]
181	SSKENYQKVLSEHGF	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. 

Sequence Annotation

  

Keyword

 Alternative initiation; Alternative promoter usage; Alternative splicing; Complete proteome; Cytoplasm; Lipoprotein; Membrane; Mitochondrion; Myristate; Nucleus; Oxidoreductase; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 235 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; TAS:ProtInc.
 GO:0006464; P:cellular protein modification process; TAS:ProtInc.
 GO:0006555; P:methionine metabolic process; TAS:ProtInc.
 GO:0006979; P:response to oxidative stress; TAS:ProtInc. 

Interpro

 IPR002569; Met_Sox_Rdtase_MsrA. 

Pfam

 PF01625; PMSR 

SMART

  

PROSITE

  

PRINTS