| Tag | Content |
|---|
| CPLM ID | CPLM-014614 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Latexin |
Protein Synonyms/Alias | Endogenous carboxypeptidase inhibitor; ECI; Tissue carboxypeptidase inhibitor; TCI |
Gene Name | Lxn |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 34 | GTPNKVFKVQTVQQA | acetylation | [1] | | 43 | QTVQQASKEDIPGRG | acetylation | [1] | | 52 | DIPGRGHKYHLKFSV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation (By similarity). |
Sequence Annotation | REGION 1 97 Cystatin-like fold 1 (By similarity).
REGION 98 118 Alpha-helical linker (By similarity).
REGION 119 223 Cystatin-like fold 2 (By similarity).
MOD_RES 56 56 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Heparin-binding; Inflammatory response; Metalloenzyme inhibitor; Metalloprotease inhibitor; Protease inhibitor; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 223 AA |
Protein Sequence | MEEIPPTHYA ASRAASVAEN CINYQQGTPN KVFKVQTVQQ ASKEDIPGRG HKYHLKFSVE 60
EIIQKQVTVS CTAEVLYPRM GQGSAPEVNF TFEGEIGKNP DEEDNTFYQR LMSMKEPLQA 120
QNIPDNFGNV SPQMKPVHHL AWVACGYVMW QNSTEDTWYK MAKIQTVKQV QRNDDFIELD 180
YTVLLHDVAS QEIIPWQMQV LWHPQYGTKV KHNSRLPKEA PAE 223 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0008201; F:heparin binding; IEA:UniProtKB-KW. GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW. GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IEA:Compara. GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |