UniProt Accession

 EIF3I_YEAST; P40217; D6VZW8 

Genbank Protein ID

 U56937; Z47071; AY558416; BK006946 

Genbank Nucleotide ID

 AAC49616.1; CAA87361.1; AAS56742.1; DAA10042.1 

Protein Name

 Eukaryotic translation initiation factor 3 subunit I 

Protein Synonyms/Alias

 eIF3i; Eukaryotic translation initiation factor 3 39 kDa subunit; eIF-3 39 kDa subunit; eIF3 p39 

Gene Name

 TIF34 

Gene Synonyms/Alias

 YMR146C; YM9375.16C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
335	DFKYDVEKAAEAKEH	acetylation	[1]
335	DFKYDVEKAAEAKEH	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. 

Sequence Annotation

 REPEAT 8 47 WD 1.
 REPEAT 50 89 WD 2.
 REPEAT 149 190 WD 3.
 REPEAT 194 233 WD 4.
 REPEAT 291 330 WD 5.
 MOD_RES 302 302 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; IDA:SGD.
 GO:0043614; C:multi-eIF complex; IDA:SGD.
 GO:0003743; F:translation initiation factor activity; IDA:SGD.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP.
 GO:0002188; P:translation reinitiation; IMP:SGD. 

Interpro

 IPR027525; eIF3i.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS