| Tag | Content |
|---|
| CPLM ID | CPLM-003982 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial-processing peptidase subunit alpha |
Protein Synonyms/Alias | Alpha-MPP |
Gene Name | MAS2 |
Gene Synonyms/Alias | MIF2; YHR024C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 184 | ELIPSISKYYLLDYR | acetylation | [1] | | 193 | YLLDYRNKFYTPENT | acetylation | [1] | | 218 | KALELTEKYLGDWQS | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Cleaves presequences (transit peptides) from mitochondrial protein precursors. The cleavage sites typically contain an arginine at position -2 (in the N-terminal portion) from the scissible peptide bond in addition to other distal basic residues, and an aromatic residue at position +1. |
Sequence Annotation | |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Hydrolase; Metalloprotease; Mitochondrion; Protease; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 482 AA |
Protein Sequence | MLRNGVQRLY SNIARTDNFK LSSLANGLKV ATSNTPGHFS ALGLYIDAGS RFEGRNLKGC 60
THILDRLAFK STEHVEGRAM AETLELLGGN YQCTSSRENL MYQASVFNQD VGKMLQLMSE 120
TVRFPKITEQ ELQEQKLSAE YEIDEVWMKP ELVLPELLHT AAYSGETLGS PLICPRELIP 180
SISKYYLLDY RNKFYTPENT VAAFVGVPHE KALELTEKYL GDWQSTHPPI TKKVAQYTGG 240
ESCIPPAPVF GNLPELFHIQ IGFEGLPIDH PDIYALATLQ TLLGGGGSFS AGGPGKGMYS 300
RLYTHVLNQY YFVENCVAFN HSYSDSGIFG ISLSCIPQAA PQAVEVIAQQ MYNTFANKDL 360
RLTEDEVSRA KNQLKSSLLM NLESKLVELE DMGRQVLMHG RKIPVNEMIS KIEDLKPDDI 420
SRVAEMIFTG NVNNAGNGKG RATVVMQGDR GSFGDVENVL KAYGLGNSSS SKNDSPKKKG 480
WF 482 |
Gene Ontology | GO:0017087; C:mitochondrial processing peptidase complex; IDA:SGD. GO:0046872; F:metal ion binding; IEA:InterPro. GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. GO:0006627; P:protein processing involved in protein targeting to mitochondrion; IMP:SGD. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |