| Tag | Content |
|---|
| CPLM ID | CPLM-000693 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras GTPase-activating protein 4 |
Protein Synonyms/Alias | Calcium-promoted Ras inactivator; Ras p21 protein activator 4; RasGAP-activating-like protein 2 |
Gene Name | RASA4 |
Gene Synonyms/Alias | CAPRI; GAPL; KIAA0538 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 569 | SLQAPPVKEGPLFIH | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. |
Sequence Annotation | DOMAIN 1 88 C2 1.
DOMAIN 129 216 C2 2.
DOMAIN 302 512 Ras-GAP.
DOMAIN 566 673 PH.
ZN_FING 675 711 Btk-type. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; GTPase activation; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 803 AA |
Protein Sequence | MAKRSSLYIR IVEGKNLPAK DITGSSDPYC IVKVDNEPII RTATVWKTLC PFWGEEYQVH 60
LPPTFHAVAF YVMDEDALSR DDVIGKVCLT RDTIASHPKG FSGWAHLTEV DPDEEVQGEI 120
HLRLEVWPGA RACRLRCSVL EARDLAPKDR NGTSDPFVRV RYKGRTRETS IVKKSCYPRW 180
NETFEFELQE GAMEALCVEA WDWDLVSRND FLGKVVIDVQ RLRVVQQEEG WFRLQPDQSK 240
SRRHDEGNLG SLQLEVRLRD ETVLPSSYYQ PLVHLLCHEV KLGMQGPGQL IPLIEETTST 300
ECRQDVATNL LKLFLGQGLA KDFLDLLFQL ELSRTSETNT LFRSNSLASK SMESFLKVAG 360
MQYLHGVLGP IINKVFEEKK YVELDPSKVE VKDVGCSGLH RPQTEAEVLE QSAQTLRAHL 420
GALLSALSRS VRACPAVVRA TFRQLFRRVR ERFPGAQHEN VPFIAVTSFL CLRFFSPAIM 480
SPKLFHLRER HADARTSRTL LLLAKAVQNV GNMDTPASRA KEAWMEPLQP TVRQGVAQLK 540
DFITKLVDIE EKDELDLQRT LSLQAPPVKE GPLFIHRTKG KGPLMSSSFK KLYFSLTTEA 600
LSFAKTPSSK KSALIKLANI RAAEKVEEKS FGGSHVMQVI YTDDAGRPQT AYLQCKCVNE 660
LNQWLSALRK VSINNTGLLG SYHPGVFRGD KWSCCHQKEK TGQGCDKTRS RVTLQEWNDP 720
LDHDLEAQLI YRHLLGVEAM LWERHRELSG GAEAGTVPTS PGKVPEDSLA RLLRVLQDLR 780
EAHSSSPAGS PPSEPNCLLE LQT 803 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:RefGenome. GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0031235; C:intrinsic to internal side of plasma membrane; ISS:RefGenome. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005099; F:Ras GTPase activator activity; ISS:RefGenome. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |