UniProt Accession

 CSK22_YEAST; P19454; D6W2C4 

Genbank Protein ID

 M33759; Z74969; Z70678; AY723867; BK006948 

Genbank Nucleotide ID

 AAA34500.1; CAA99254.1; CAA94546.1; AAU09784.1; DAA10840.1 

Protein Name

 Casein kinase II subunit alpha' 

Protein Synonyms/Alias

 CK II 

Gene Name

 CKA2 

Gene Synonyms/Alias

 YOR061W; YOR29-12 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
55	SNYEIINKIGRGKYS	acetylation	[1]
60	INKIGRGKYSEVFSG	acetylation	[1]
169	GIMHRDVKPQNVMID	ubiquitination	[2]
245	FKKEPFFKGSSNPDQ	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. May play a role in cell proliferation. Required for cell viability. 

Sequence Annotation

 DOMAIN 50 334 Protein kinase.
 NP_BIND 56 64 ATP (By similarity).
 ACT_SITE 167 167 Proton acceptor (By similarity).
 BINDING 79 79 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0005956; C:protein kinase CK2 complex; IDA:SGD.
 GO:0034456; C:UTP-C complex; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:SGD.
 GO:0001300; P:chronological cell aging; IMP:SGD.
 GO:0007535; P:donor selection; IGI:SGD.
 GO:0006356; P:regulation of transcription from RNA polymerase I promoter; IDA:SGD.
 GO:0006359; P:regulation of transcription from RNA polymerase III promoter; IDA:SGD.
 GO:0006974; P:response to DNA damage stimulus; IDA:SGD. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS