| Tag | Content |
|---|
| CPLM ID | CPLM-008979 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cadherin-5 |
Protein Synonyms/Alias | Vascular endothelial cadherin; VE-cadherin; CD144 |
Gene Name | Cdh5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 690 | AVYTQVQKPPRLAPG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. |
Sequence Annotation | DOMAIN 46 149 Cadherin 1.
DOMAIN 150 256 Cadherin 2.
DOMAIN 257 371 Cadherin 3.
DOMAIN 372 476 Cadherin 4.
DOMAIN 477 593 Cadherin 5.
CARBOHYD 59 59 N-linked (GlcNAc...) (Potential).
CARBOHYD 155 155 N-linked (GlcNAc...) (Potential).
CARBOHYD 441 441 N-linked (GlcNAc...) (Potential).
CARBOHYD 523 523 N-linked (GlcNAc...) (Potential).
CARBOHYD 535 535 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Calcium; Cell adhesion; Cell junction; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 784 AA |
Protein Sequence | MQRLTELATA LGAFLGLLAV AAMAGPNFPQ IDTPNMLPAH HRQKRDWIWN QMHIDEEKNE 60
SLPHYVGKIK SNVNRQNAKY VLQGEFAGKI FGVDANTGNV LAYERLDREK VSEYFLTALI 120
VDKNTNKNLE QPSSFTVKVH DINDNWPVFS HQVFNASVPE MSAIGTSVIR VTAVDADDPT 180
VAGHATVLYQ IVKGNEYFSI DNSGLIFTKI KNLDREKQAE YKIVVETQDA LGLRGESGTA 240
TVMIRLEDIN DNFPVFTQST YTFSVPEDIR VGKPLGFLTV VDPDEPQNRM TKYSIMQGEY 300
RDTFTIETDP KRNEGIIKPT KSLDYEVIQQ YTFYIEATDP TIRYEYLSST SGKNKAMVTI 360
NVLDVDEPPV FQRHFYHFKL PENQKKPLIG TVVAKDPDKA QRSIGYSIRK TSDRGQFFRI 420
TKQGNIYNEK ELDRETYAWY NLTVEANELD SRGNPVGKES IVQVYIEVLD ENDNPPEFAQ 480
PYEPKVCENA AQGKLVVQIS ATDKDVVPVN PKFKFALKNE DSNFTLINNH DNTANITVKY 540
GQFNREHAKF HYLPVLISDN GVPSLTGTST LTVGVCKCNE QGEFTFCEEM AAQAGVSIQA 600
LVAIFLCILT ITVITLLIIL RRRIRKQAHA HSKSALEIHE QLVTYDEEGG GEMDTTSYDV 660
SVLNSVRGGS TKPLRSTMDA RPAVYTQVQK PPRLAPGLHG GPREMATMID VKKEEADNDG 720
GGPPYDTLHI YGYEGAESIA ESLSSLSTNS SDSDIDYDFL NDWGPRFKML AELYGSDPQE 780
ELII 784 |
Gene Ontology | GO:0071944; C:cell periphery; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005923; C:tight junction; IDA:MGI. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0001955; P:blood vessel maturation; IMP:MGI. GO:0016337; P:cell-cell adhesion; IMP:MGI. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. GO:0008285; P:negative regulation of cell proliferation; IGI:MGI. GO:2000114; P:regulation of establishment of cell polarity; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |