CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032298
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FGD5 protein 
Protein Synonyms/Alias
 FYVE, RhoGEF and PH domain-containing protein 5 
Gene Name
 FGD5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
734SNWESQQKVADVFLAubiquitination[1]
792QGGSQTAKHRLLRVVubiquitination[1]
875QPGREFLKEGTLMKVubiquitination[1]
881LKEGTLMKVTGKNRRubiquitination[1]
913KDGKYRLKNTLAVANubiquitination[1]
1060DGCFGELKKRGRAVPubiquitination[1]
1105INPSTFKKQKKVPSAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1178 AA 
Protein Sequence
MGQDAEDTSE EPPEKEELAG VQEAETATDC PEVLEEGCEE ATGVTGGEQV DLSEPPDHEK 60
KTNQEVAAAT LEDHAQDESA EESCQIVPFE NDCMEDFVTS LTGSPYEFFP TESTSFCSES 120
CSPLSESAKG LESEQAPKLG LRAEENPMVG ALCGQCGSLQ GGAAEGPAAP DVVVVLEEEA 180
LDDALANPYV MGVGLPGQAA PGEGGQAASD ALGGYGSKEE LNCEAEGGLV PADRKNTSTR 240
VRPHSGKVAG YVPETVPEET GPEAGSSAPG IGGAAEEVGK TLLSLEGKPL EASRALPAKP 300
RAFTLYPRSF SVEGREIPVS VYQEPEGSGL DDHRIKRKED NLSLSCVIGS SGSFSQRNHL 360
PSSGTSTPSS MVDIPPPFDL ACITKKPITK SSPSLLIESD SPDKYKKKKS SFKRFLALTF 420
KKKTENKLHV DVNVSSSRSS SESSYHGPSR ILEVDRRSLS NSPQLKSRTG KLRASESPSS 480
LIFYRDGKRK GVPFSRTVSR VESFEDRSRP PFLPLPLTKP RSISFPSADT SDYENIPAMN 540
SDYENIQIPP RRPARAGAFT KLFEDQSRAL STANENDGYV DMSSFNAFES KQQSADQDAE 600
SAYTEPYKVC PISSAAPKED LTSDEEQRSS EEEDSASRDP SVTHKVEGQS RALVIAQELL 660
SSEKAYVEML QHLNLDFHGA VMRALDDMDH EGRDTLAREE LRQGLSELPA IHDLHQGILE 720
ELEERLSNWE SQQKVADVFL AREQGFDHHA THILQFDRYL GLLSENCLHS PRLAAAVREF 780
EQSVQGGSQT AKHRLLRVVQ RLFQYQVLLT DYLNNLCPDS AEYDNTQGAL SLISKVTDRA 840
NDSMEQGENL QKLVHIEHSV RGQGDLLQPG REFLKEGTLM KVTGKNRRPR HLFLMNDVLL 900
YTYPQKDGKY RLKNTLAVAN MKVSRPVMEK VPYALKIETS ESCLMLSASS CAERDEWYGC 960
LSRALPEDYK AQALAAFHHS VEIRERLGVS LGERPPTLVP VTHVMMCMNC GCDFSLTLRR 1020
HHCHACGKIV CRNCSRNKYP LKYLKDRMAK VCDGCFGELK KRGRAVPGLM RERPVSMSFP 1080
LSSPRFSGSA FSSVFQSINP STFKKQKKVP SALTEDKVAL ESMPLLGFTI APEKEEGSSE 1140
VGPIFHLYHK KTLFYSFKAE DTNSAQRWIE AMEDASVL 1178 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00064; FYVE
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50178; ZF_FYVE 
PRINTS